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dc.contributor.authorSantos-García, Diego
dc.contributor.authorde Deus Fonticoba, Teresa
dc.contributor.authorBartolomé, Carlos Cores
dc.contributor.authorPainceiras, Maria J Feal
dc.contributor.authorCastro, Ester Suárez
dc.contributor.authorCanfield, Héctor
dc.contributor.authorMiró, Cristina Martínez
dc.contributor.authorJesús, Silvia
dc.contributor.authorAguilar, Miquel
dc.contributor.authorPastor, Pau
dc.contributor.authorPlanellas, Lluís
dc.contributor.authorCosgaya, Marina
dc.contributor.authorCaldentey, Juan García
dc.contributor.authorCaballol, Nuria
dc.contributor.authorLegarda, Ines
dc.contributor.authorHernández-Vara, Jorge
dc.contributor.authorCabo, Iria
dc.contributor.authorManzanares, Lydia López
dc.contributor.authorAramburu, Isabel González
dc.contributor.authorRivera, Maria A Ávila
dc.contributor.authorMayordomo, Víctor Gómez
dc.contributor.authorNogueira, Víctor
dc.contributor.authorPuente, Víctor
dc.contributor.authorGarcía-Soto, Julio Dotor
dc.contributor.authorBorrué, Carmen
dc.contributor.authorVila, Berta Solano
dc.contributor.authorSauco, María Álvarez
dc.contributor.authorVela, Lydia
dc.contributor.authorEscalante, Sonia
dc.contributor.authorCubo, Esther
dc.contributor.authorPadilla, Francisco Carrillo
dc.contributor.authorCastrillo, Juan C Martínez
dc.contributor.authorAlonso, Pilar Sánchez
dc.contributor.authorLosada, Maria G Alonso
dc.contributor.authorAriztegui, Nuria López
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky, Jaime
dc.contributor.authorEstrada, Marta Blázquez
dc.contributor.authorSeijo, Manuel
dc.contributor.authorMartínez, Javier Rúiz
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica
dc.contributor.authorde Fábregues, Oriol
dc.contributor.authorArdura, Jessica González
dc.contributor.authorRedondo, Ruben Alonso
dc.contributor.authorOrdás, Carlos
dc.contributor.authorDíaz, Luis M López
dc.contributor.authorMcAfee, Darrian
dc.contributor.authorMartinez-Martin, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorCoppadis Study Group
dc.date.accessioned2022-05-31T13:27:12Z
dc.date.available2022-05-31T13:27:12Z
dc.date.issued2022-05-05
dc.identifier.urihttp://hdl.handle.net/10713/19025
dc.description.abstractObjective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score ≥ 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 ± 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 ± 36.48 vs. 34.3 ± 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 ± 37.37) compared to those who did not develop MF (+6.2 ± 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (β = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.en_US
dc.description.urihttps://doi.org/10.3390/diagnostics12051147en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofDiagnostics (Basel, Switzerland)en_US
dc.subjectParkinson’s diseaseen_US
dc.subjectburdenen_US
dc.subjectfollow-upen_US
dc.subjectmotor fluctuationsen_US
dc.subjectnon-motor symptomsen_US
dc.titleMotor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/diagnostics12051147
dc.identifier.pmid35626303
dc.source.journaltitleDiagnostics (Basel, Switzerland)
dc.source.volume12
dc.source.issue5
dc.source.countrySwitzerland


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