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dc.contributor.authorDoub, James B
dc.contributor.authorNg, Vincent Y
dc.contributor.authorLee, Myounghee
dc.contributor.authorChi, Andrew
dc.contributor.authorLee, Alina
dc.contributor.authorWürstle, Silvia
dc.contributor.authorChan, Benjamin
dc.date.accessioned2022-05-31T13:14:08Z
dc.date.available2022-05-31T13:14:08Z
dc.date.issued2022-05-04
dc.identifier.urihttp://hdl.handle.net/10713/19020
dc.description.abstractProsthetic joint infections are a devastating complication of joint replacement surgery. Consequently, novel therapeutics are needed to thwart the significant morbidity and enormous financial ramifications that are associated with conventional treatments. One such promising adjuvant therapeutic is bacteriophage therapy given its antibiofilm activity and its ability to self-replicate. Herein we discuss the case of a 70-year-old female who had a recalcitrant MRSA prosthetic knee and femoral lateral plate infection who was successfully treated with adjuvant bacteriophage therapy. Moreover, this case discusses the importance of propagating bacteriophage therapeutics on bacteria that are devoid of toxins and the need to ensure bacteriophage activity to all bacterial morphologies. Overall, this case reinforces the potential benefit of using personalized bacteriophage therapy for recalcitrant prosthetic joint infections, but more translational research is needed to thereby devise effective, reproducible clinical trials. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.urihttps://doi.org/10.3390/antibiotics11050616en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofAntibiotics (Basel, Switzerland)en_US
dc.subjectStaphylococcus aureusen_US
dc.subjectbacteriophage therapyen_US
dc.subjectcell surface receptoren_US
dc.subjectprosthetic joint infectionen_US
dc.subjecttransaminitisen_US
dc.titleSalphage: Salvage Bacteriophage Therapy for Recalcitrant MRSA Prosthetic Joint Infection.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/antibiotics11050616
dc.identifier.pmid35625260
dc.source.journaltitleAntibiotics (Basel, Switzerland)
dc.source.volume11
dc.source.issue5
dc.source.countrySwitzerland


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