PublisherAmerican Society for Microbiology
MetadataShow full item record
AbstractWhat causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org/10.1128/mbio.03197-21) used a mouse model and cellular studies to investigate bacterial and host factors that contribute to cough production during Bordetella pertussis infection. In elegant studies, they found that the bacterial factors pertussis toxin, lipooligosaccharide, and Vag8 function cooperatively to produce cough. These factors induce production of host bradykinin, a known cough inducer that sensitizes the ion channel TRPV1 on neurons, and they investigated host signaling pathways altered by the bacterial factors that exacerbate cough responses. This is a highly significant and important finding that not only elucidates mechanisms underlying the pathophysiology of the severe cough, but also may reveal potential novel therapeutic approaches to treat individuals suffering from the debilitating effects of cough in pertussis.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18995
- The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model.
- Authors: Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, Horiguchi Y
- Issue date: 2022 Apr 26
- Virulence Associated Gene 8 of <i>Bordetella pertussis</i> Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor.
- Authors: Hovingh ES, de Maat S, Cloherty APM, Johnson S, Pinelli E, Maas C, Jongerius I
- Issue date: 2018
- Emergence of Bordetella holmesii as a Causative Agent of Whooping Cough, Barcelona, Spain.
- Authors: Mir-Cros A, Codina G, Martín-Gómez MT, Fàbrega A, Martínez X, Jané M, Van Esso D, Cornejo T, Rodrigo C, Campins M, Pumarola T, González-López JJ
- Issue date: 2017 Nov
- Probing the Genome-Scale Metabolic Landscape of Bordetella pertussis, the Causative Agent of Whooping Cough.
- Authors: Branco Dos Santos F, Olivier BG, Boele J, Smessaert V, De Rop P, Krumpochova P, Klau GW, Giera M, Dehottay P, Teusink B, Goffin P
- Issue date: 2017 Nov 1
- Whooping Cough in Adults: A Series of Severe Cases.
- Authors: Zycinska K, Cieplak M, Chmielewska M, Nitsch-Osuch A, Klaczkow A, Hadzik-Blaszczyk M, Kur Z, Wardyn KA
- Issue date: 2017