Cryptic Genes for Interbacterial Antagonism Distinguish Species Infecting Blacklegged Ticks From Other Pathogens.
AuthorVerhoeve, Victoria I
Fauntleroy, Tyesha D
Risteen, Riley G
Driscoll, Timothy P
Gillespie, Joseph J
JournalFrontiers in Cellular and Infection Microbiology
PublisherFrontiers Media S.A.
MetadataShow full item record
AbstractThe genus Rickettsia (Alphaproteobacteria: Rickettsiales) encompasses numerous obligate intracellular species with predominantly ciliate and arthropod hosts. Notable species are pathogens transmitted to mammals by blood-feeding arthropods. Mammalian pathogenicity evolved from basal, non-pathogenic host-associations; however, some non-pathogens are closely related to pathogens. One such species, Rickettsia buchneri, is prevalent in the blacklegged tick, Ixodes scapularis. While I. scapularis transmits several pathogens to humans, it does not transmit Rickettsia pathogens. We hypothesize that R. buchneri established a mutualism with I. scapularis, blocking tick superinfection with Rickettsia pathogens.
Data AvailibilityThe original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author.
Rights/TermsCopyright © 2022 Verhoeve, Fauntleroy, Risteen, Driscoll and Gillespie.
contact-dependent growth inhibition systems
lateral gene transfer
recombination hot spot
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18990
- Conjugative Transposons and Their Cargo Genes Vary across Natural Populations of Rickettsia buchneri Infecting the Tick Ixodes scapularis.
- Authors: Hagen R, Verhoeve VI, Gillespie JJ, Driscoll TP
- Issue date: 2018 Dec 1
- Tick Cell Culture Analysis of Growth Dynamics and Cellular Tropism of <i>Rickettsia buchneri</i>, an Endosymbiont of the Blacklegged Tick, <i>Ixodes scapularis</i>.
- Authors: Thorpe CJ, Wang XR, Munderloh UG, Kurtti TJ
- Issue date: 2021 Oct 27
- The <i>Ixodes scapularis</i> Symbiont <i>Rickettsia buchneri</i> Inhibits Growth of Pathogenic Rickettsiaceae in Tick Cells: Implications for Vector Competence.
- Authors: Cull B, Burkhardt NY, Wang XR, Thorpe CJ, Oliver JD, Kurtti TJ, Munderloh UG
- Issue date: 2021
- A Rickettsia genome overrun by mobile genetic elements provides insight into the acquisition of genes characteristic of an obligate intracellular lifestyle.
- Authors: Gillespie JJ, Joardar V, Williams KP, Driscoll T, Hostetler JB, Nordberg E, Shukla M, Walenz B, Hill CA, Nene VM, Azad AF, Sobral BW, Caler E
- Issue date: 2012 Jan
- Growth Dynamics and Antibiotic Elimination of Symbiotic Rickettsia buchneri in the Tick Ixodes scapularis (Acari: Ixodidae).
- Authors: Oliver JD, Price LD, Burkhardt NY, Heu CC, Khoo BS, Thorpe CJ, Kurtti TJ, Munderloh UG
- Issue date: 2021 Jan 15