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dc.contributor.authorFrid, P
dc.contributor.authorXu, H
dc.contributor.authorMitchell, B D
dc.contributor.authorDrake, M
dc.contributor.authorWasselius, J
dc.contributor.authorGaynor, B
dc.contributor.authorRyan, K
dc.contributor.authorGiese, A K
dc.contributor.authorSchirmer, M
dc.contributor.authorDonahue, K L
dc.contributor.authorIrie, R
dc.contributor.authorBouts, M J R J
dc.contributor.authorMcIntosh, E C
dc.contributor.authorMocking, S J T
dc.contributor.authorDalca, A V
dc.contributor.authorGiralt-Steinhauer, E
dc.contributor.authorHolmegaard, L
dc.contributor.authorJood, K
dc.contributor.authorRoquer, J
dc.contributor.authorCole, J W
dc.contributor.authorMcArdle, P F
dc.contributor.authorBroderick, J P
dc.contributor.authorJimenez-Conde, J
dc.contributor.authorJern, C
dc.contributor.authorKissela, B M
dc.contributor.authorKleindorfer, D O
dc.contributor.authorLemmens, R
dc.contributor.authorMeschia, J F
dc.contributor.authorRosand, J
dc.contributor.authorRundek, T
dc.contributor.authorSacco, R L
dc.contributor.authorSchmidt, R
dc.contributor.authorSharma, P
dc.contributor.authorSlowik, A
dc.contributor.authorThijs, V
dc.contributor.authorWoo, D
dc.contributor.authorWorrall, B B
dc.contributor.authorKittner, S J
dc.contributor.authorPetersson, J
dc.contributor.authorGolland, P
dc.contributor.authorWu, O
dc.contributor.authorRost, N S
dc.contributor.authorLindgren, A
dc.date.accessioned2022-05-23T10:51:08Z
dc.date.available2022-05-23T10:51:08Z
dc.date.issued2022-05-13
dc.identifier.urihttp://hdl.handle.net/10713/18956
dc.description.abstractObjective: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. Methods: Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype. Results: Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01–0.03) and decreased risk of ACiS (p=0.010–0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008–0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001–0.010) and migraine without aura (p=0.032–0.048). Migraine with aura PRS did not show a differential association in our analyses. Conclusions: Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function. © 2022 The Authorsen_US
dc.description.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106546en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Stroke and Cerebrovascular Diseasesen_US
dc.rightsCopyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.en_US
dc.subjectCommon genetic variantsen_US
dc.subjectMRI phenotypeen_US
dc.subjectMigraineen_US
dc.subjectPosterior circulation ischemic strokeen_US
dc.titleMigraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke☆.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2022.106546
dc.identifier.pmid35576861
dc.source.journaltitleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
dc.source.volume31
dc.source.issue8
dc.source.beginpage106546
dc.source.endpage
dc.source.countryUnited States


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