Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures.
AuthorStewart, Christopher C
O'Hara, Nathan N
Bahney, Chelsea S
Slobogean, Gerard P
JournalBone & Joint Research
PublisherBritish Editorial Society of Bone & Joint Surgery
MetadataShow full item record
AbstractA total of 102 participants aged 18 to 50 years (median 28 years (interquartile range 23 to 35)), receiving an intramedullary nail for a tibial or femoral shaft fracture, were enrolled in a randomized controlled trial comparing vitamin D3 supplementation to placebo. Serum C-terminal telopeptide of type I collagen (CTX; bone resorption marker) and N-terminal propeptide of type I procollagen (P1NP; bone formation marker) were measured at baseline, six weeks, and 12 weeks post-injury. Clinical and radiological fracture healing was assessed at three months.
KeywordBone turnover marker
Bone turnover markers
femoral shaft fractures
randomized controlled trial
type I collagen
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18923
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Fixation using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Exploratory Health-Related Quality of Life and Patient-Reported Functional Outcomes of a Multi-Centre 2 × 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients.Slobogean, Gerard P; Sprague, Sheila; Bzovsky, Sofia; Scott, Taryn; Thabane, Lehana; Heels-Ansdell, Diane; O'Toole, Robert V; Howe, Andrea; Gaski, Greg E; Hill, Lauren C; et al. (Elsevier Ltd., 2021-02-14)Patients between the ages of 18-60 years with a femoral neck fracture requiring surgical fixation were eligible. Eligible patients were randomized to receive either a sliding hip screw or cancellous screws for fracture fixation AND vitamin D3 4,000 IU or placebo daily for 6 months. Patient-reported function (Hip Outcome Score) and HRQL (Short Form-12) were assessed at standardized time points in the 12 months following their fixation surgery. Patient-reported function and HRQL were summarized using means, SD, and 95% confidence intervals (CIs), or percentages and counts. Longitudinal data analysis with mixed models was used to explore the effect of treatment group and time on the patient-reported function and HRQL.
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