Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures.
AuthorStewart, Christopher C
O'Hara, Nathan N
Bahney, Chelsea S
Slobogean, Gerard P
JournalBone & Joint Research
PublisherBritish Editorial Society of Bone & Joint Surgery
MetadataShow full item record
AbstractA total of 102 participants aged 18 to 50 years (median 28 years (interquartile range 23 to 35)), receiving an intramedullary nail for a tibial or femoral shaft fracture, were enrolled in a randomized controlled trial comparing vitamin D3 supplementation to placebo. Serum C-terminal telopeptide of type I collagen (CTX; bone resorption marker) and N-terminal propeptide of type I procollagen (P1NP; bone formation marker) were measured at baseline, six weeks, and 12 weeks post-injury. Clinical and radiological fracture healing was assessed at three months.
KeywordBone turnover marker
Bone turnover markers
femoral shaft fractures
randomized controlled trial
type I collagen
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18923
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Fracture Strength of Repaired Midline Fractures of Maxillary DentureTAN, YINGHAN; Masri, Radi, 1975- (2013)Statement of problem: Denture fracture is a frequent clinical problem faced by the dentist. Denture repair should be simple to perform, cost-effective and quick. Unfortunately, the current methods of repair do not meet all of these requirements. Cyanoacrylate is a conveniently available adhesive material and it has been used by some patients to temporarily repair dentures before they get new ones. It is easy to use and relatively inexpensive. However, there is no literature that lists cyanoacrylate as a type of denture repair material. Purpose: This study investigated the transverse fracture strength of denture bases repaired with cyanoacrylates (Loctite Superglue Liquid, Loctite Superglue Liquid Professional). This was compared with denture bases repaired with auto-polymerizing acrylic resin (Lucitone 199 Repair Material). Material and methods: Thirty maxillary denture specimens were prepared and tested. They were divided into 3 different groups. Each of them was prepared with a clean midline fracture, repaired with Loctite Superglue Liquid, Loctite Superglue Liquid Professional or Lucitone 199 Repair Material and tested using the Universal Testing Machine. Data were analyzed using 1-way ANOVA and Tukey's HSD test, α=0.05. Results: There was a significant difference among the 3 types of repair materials. There was no significant difference in transverse fracture strength between Loctite Superglue Liquid Professional (107.16 ±20.57 MPa) and Lucitone 199 Repair Material (128.90 ±22.08 MPa). Loctite Superglue Liquid (53.79 ±19.05 MPa) had significant less transverse fracture strength than the other 2 types of material. Conclusion: Within the limitations of this study, cyanoacrylate containing methyl methacrylate polymer (Loctite Superglue Liquid Professional) is an inexpensive and readily available material which can be used as a temporary measure to repair dentures with a clean fracture. However, further studies are required to investigate the long term cytotoxicity and intraoral stability of the material.
Fixation using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Exploratory Health-Related Quality of Life and Patient-Reported Functional Outcomes of a Multi-Centre 2 × 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients.Slobogean, Gerard P; Sprague, Sheila; Bzovsky, Sofia; Scott, Taryn; Thabane, Lehana; Heels-Ansdell, Diane; O'Toole, Robert V; Howe, Andrea; Gaski, Greg E; Hill, Lauren C; et al. (Elsevier Ltd., 2021-02-14)Patients between the ages of 18-60 years with a femoral neck fracture requiring surgical fixation were eligible. Eligible patients were randomized to receive either a sliding hip screw or cancellous screws for fracture fixation AND vitamin D3 4,000 IU or placebo daily for 6 months. Patient-reported function (Hip Outcome Score) and HRQL (Short Form-12) were assessed at standardized time points in the 12 months following their fixation surgery. Patient-reported function and HRQL were summarized using means, SD, and 95% confidence intervals (CIs), or percentages and counts. Longitudinal data analysis with mixed models was used to explore the effect of treatment group and time on the patient-reported function and HRQL.
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