Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.
AuthorValk, Sofie L
Bethlehem, Richard A I
Vos de Wael, Reinder
Masouleh, Shahrzad Kharabian
Yeo, B T Thomas
Eickhoff, Simon B
Bernhardt, Boris C
MetadataShow full item record
AbstractBrain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
Data / Code Locationhttps://doi.org/10.1038/s41467-022-29886-1#data-availability; https://doi.org/10.1038/s41467-022-29886-1#code-availability; https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-29886-1/MediaObjects/41467_2022_29886_MOESM5_ESM.xlsx
Rights/Terms© 2022. The Author(s).
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18822
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