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    Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.

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    Author
    Valk, Sofie L
    Xu, Ting
    Paquola, Casey
    Park, Bo-Yong
    Bethlehem, Richard A I
    Vos de Wael, Reinder
    Royer, Jessica
    Masouleh, Shahrzad Kharabian
    Bayrak, Şeyma
    Kochunov, Peter
    Yeo, B T Thomas
    Margulies, Daniel
    Smallwood, Jonathan
    Eickhoff, Simon B
    Bernhardt, Boris C
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    Date
    2022-05-09
    Journal
    Nature Communications
    Publisher
    Springer Nature
    Type
    Article
    
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    See at
    https://doi.org/10.1038/s41467-022-29886-1
    Abstract
    Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.
    Rights/Terms
    © 2022. The Author(s).
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18822
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-022-29886-1
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