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dc.contributor.authorVeldhuijzen, Dieuwke S
dc.contributor.authorMeeker, Timothy J
dc.contributor.authorBauer, Deborah
dc.contributor.authorKeaser, Michael L
dc.contributor.authorGullapalli, Rao P
dc.contributor.authorGreenspan, Joel D
dc.date.accessioned2022-05-11T17:04:37Z
dc.date.available2022-05-11T17:04:37Z
dc.date.issued2022-05-05
dc.identifier.urihttp://hdl.handle.net/10713/18809
dc.description.abstractIntroduction: Bidirectional effects between cognition and pain have been extensively reported. Although brain regions involved in cognitive and pain processing seem to partly overlap, it is unknown what specific brain regions are involved in the interaction between pain and cognition. Furthermore, the role of gonadal hormones on these interacting effects has not been examined. This study investigated brain activation patterns of the interaction between pain and cognition over different phases of the naturally occurring menstrual cycle. Methods: Fifteen healthy normally cycling females were examined over the course of 4 different cycle phases. Sensory stimulation was applied using electrical pulses and cognitive performance was assessed using the Multi-Source Interference Task. Brain imaging consisted of functional magnetic resonance imaging using a repeated measures ANOVA group analysis approach. Results: Sensory stimulation was found to interact with task performance in the left precuneus, left posterior cingulate cortex and right inferior parietal lobule. No effects of cycle phase were observed to interact with main effects of stimulation, task or interaction effects between task performance and sensory stimulation. Conclusion: Potential neural correlates of shared resources between pain and cognition were demonstrated providing further insights into the potential mechanisms behind cognitive performance difficulties in pain patients and opening avenues for new treatment options including targeting specific cognitive factors in pain treatment such as cognitive interference.en_US
dc.description.urihttps://doi.org/10.1002/brb3.2593en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofBrain and Behavioren_US
dc.rights© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.en_US
dc.subjectMSITen_US
dc.subjectcognitive performanceen_US
dc.subjectelectrical painen_US
dc.subjectgonadal hormonesen_US
dc.subjectmenstrual cycleen_US
dc.titleBrain responses to painful electrical stimuli and cognitive tasks interact in the precuneus, posterior cingulate cortex, and inferior parietal cortex and do not vary across the menstrual cycle.en_US
dc.typeArticleen_US
dc.identifier.doi10.1002/brb3.2593
dc.identifier.pmid35510527
dc.source.journaltitleBrain and behavior
dc.source.beginpagee2593
dc.source.endpage
dc.source.countryUnited States


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