Copeptin Levels Before and After Transsphenoidal Surgery for Cushing Disease: A Potential Early Marker of Remission.
Author
Flippo, ChelsiTatsi, Christina
Sinaii, Ninet
Sierra, Maria De La Luz
Belyavskaya, Elena
Lyssikatos, Charalampos
Keil, Meg
Spanakis, Elias
Stratakis, Constantine A
Date
2022-04-06Journal
Journal of the Endocrine SocietyPublisher
Oxford University PressType
Article
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Forty-four patients (64% female, aged 7-55 years) were included, and 19 developed neither diabetes insipidus (DI) or syndrome of inappropriate anti-diuresis (SIADH). Thirty-three had follow-up at least 3 months postoperatively. There was no difference in peak postoperative copeptin in remission (6.1 pmol/L [4.3-12.1]) vs no remission (7.3 pmol/L [5.4-8.4], P = 0.88). Excluding those who developed DI or SIADH, there was no difference in peak postoperative copeptin in remission (10.2 pmol/L [6.9-21.0]) vs no remission (5.4 pmol/L [4.6-7.3], P = 0.20). However, a higher peak postoperative copeptin level was found in those in remission (14.6 pmol/L [±10.9] vs 5.8 (±1.4), P = 0.03]) with parametric testing. There was no difference in the Δcopeptin by remission status.Rights/Terms
Published by Oxford University Press on behalf of the Endocrine Society 2022.Identifier to cite or link to this item
http://hdl.handle.net/10713/18806ae974a485f413a2113503eed53cd6c53
10.1210/jendso/bvac053
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