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    Copeptin Levels Before and After Transsphenoidal Surgery for Cushing Disease: A Potential Early Marker of Remission.

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    Author
    Flippo, Chelsi
    Tatsi, Christina
    Sinaii, Ninet
    Sierra, Maria De La Luz
    Belyavskaya, Elena
    Lyssikatos, Charalampos
    Keil, Meg
    Spanakis, Elias
    Stratakis, Constantine A
    Date
    2022-04-06
    Journal
    Journal of the Endocrine Society
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1210/jendso/bvac053
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9070476/
    Abstract
    Forty-four patients (64% female, aged 7-55 years) were included, and 19 developed neither diabetes insipidus (DI) or syndrome of inappropriate anti-diuresis (SIADH). Thirty-three had follow-up at least 3 months postoperatively. There was no difference in peak postoperative copeptin in remission (6.1 pmol/L [4.3-12.1]) vs no remission (7.3 pmol/L [5.4-8.4], P = 0.88). Excluding those who developed DI or SIADH, there was no difference in peak postoperative copeptin in remission (10.2 pmol/L [6.9-21.0]) vs no remission (5.4 pmol/L [4.6-7.3], P = 0.20). However, a higher peak postoperative copeptin level was found in those in remission (14.6 pmol/L [±10.9] vs 5.8 (±1.4), P = 0.03]) with parametric testing. There was no difference in the Δcopeptin by remission status.
    Rights/Terms
    Published by Oxford University Press on behalf of the Endocrine Society 2022.
    Keyword
    Cushing disease
    copeptin
    cortisol
    remission
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18806
    ae974a485f413a2113503eed53cd6c53
    10.1210/jendso/bvac053
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