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    Humoral immunity against SARS-CoV-2 variants including omicron in solid organ transplant recipients after three doses of a COVID-19 mRNA vaccine.

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    Author
    Saharia, Kapil K
    Husson, Jennifer S
    Niederhaus, Silke V
    Iraguha, Thierry
    Avila, Stephanie V
    Yoo, Youngchae J
    Hardy, Nancy M
    Fan, Xiaoxuan
    Omili, Destiny
    Crane, Alice
    Carrier, Amber
    Xie, Wen Y
    Vander Mause, Erica
    Hankey, Kim
    Bauman, Sherri
    Lesho, Patricia
    Mannuel, Heather D
    Ahuja, Ashish
    Mathew, Minu
    Avruch, James
    Baddley, John
    Goloubeva, Olga
    Shetty, Kirti
    Dahiya, Saurabh
    Rapoport, Aaron P
    Luetkens, Tim
    Atanackovic, Djordje
    Show allShow less

    Date
    2022-04-29
    Journal
    Clinical & Translational Immunology
    Publisher
    Wiley-Blackwell
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/cti2.1391
    Abstract
    Following the initial vaccination series, 60.3% of SOTR showed no measurable neutralisation and only 18.9% demonstrated neutralising activity of > 90%. More intensive immunosuppression, antimetabolites in particular, negatively impacted antiviral immunity. While absolute IgG levels were lower in SOTR than controls, antibody titres against microbial recall antigens were higher. By contrast, SOTR showed reduced vaccine-induced IgG/IgA antibody titres against SARS-CoV-2 and its delta variants and fewer linear B-cell epitopes, indicating reduced B-cell diversity. Importantly, a third vaccine dose led to an increase in anti-SARS-CoV-2 antibody titres and neutralising activity across alpha, beta and delta variants and to the induction of anti-SARS-CoV-2 CD4+ T cells in a subgroup of patients analysed. By contrast, we observed significantly lower antibody titres after the third dose with the omicron variant compared to the ancestral SARS-CoV-2 and the improvement in neutralising activity was much less pronounced than for all the other variants.
    Rights/Terms
    © 2022 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
    Keyword
    COVID‐19
    SARS‐CoV‐2
    antibody responses
    omicron variant
    solid organ transplant
    vaccine
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18773
    ae974a485f413a2113503eed53cd6c53
    10.1002/cti2.1391
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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