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dc.contributor.authorLi, Yue-Xin
dc.contributor.authorLi, Jia-Heng
dc.contributor.authorGuo, Yi
dc.contributor.authorTao, Zhuo-Ying
dc.contributor.authorQin, Shi-Hao
dc.contributor.authorTraub, Richard J
dc.contributor.authorAn, Hong
dc.contributor.authorCao, Dong-Yuan
dc.date.accessioned2022-05-04T12:21:56Z
dc.date.available2022-05-04T12:21:56Z
dc.date.issued2022-04-21
dc.identifier.urihttp://hdl.handle.net/10713/18741
dc.description.abstractOxytocin (OT) is recognized as a critical neuropeptide in pain-related disorders. Chronic pain caused by the comorbidity of temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) is common, but whether OT plays an analgesic role in the comorbidity of TMD and FMS is unknown. Female rats with masseter muscle inflammation combined with 3-day forced swim (FS) stress developed somatic hypersensitivity, which modeled the comorbidity of TMD and FMS. Using this model, the effects of spinal OT administration on mechanical allodynia and thermal hyperalgesia in hindpaws were examined. Furthermore, the protein levels of OT receptors and 5-HT2A receptors in the L4-L5 spinal dorsal horn were analyzed by Western blot. The OT receptor antagonist atosiban and 5-HT2A receptor antagonist ritanserin were intrathecally injected prior to OT injection in the separate groups. Intrathecal injection of 0.125 μg and 0.5 μg OT attenuated the hindpaw hyperalgesia. The expression of OT receptors and 5-HT2A receptors in the L4-L5 spinal dorsal horn significantly increased following intrathecal injection of 0.5 μg OT. Intrathecal administration of either the OT receptor antagonist atosiban or 5-HT2A receptor antagonist ritanserin blocked the analgesic effect of OT. These results suggest that OT may inhibit hindpaw hyperalgesia evoked by orofacial inflammation combined with stress through OT receptors and/or 5-HT2A receptors, thus providing a therapeutic prospect for drugs targeting the OT system and for patients with comorbidity of TMD and FMS.en_US
dc.description.urihttps://doi.org/10.1177%2F17448069221089591en_US
dc.language.isoenen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofMolecular Painen_US
dc.subjectfibromyalgia syndromeen_US
dc.subjectoxytocinen_US
dc.subjectpainen_US
dc.subjectserotoninen_US
dc.subjecttemporomandibular disorderen_US
dc.titleOxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress.en_US
dc.typeArticleen_US
dc.identifier.doi10.1177/17448069221089591
dc.identifier.pmid35266833
dc.source.journaltitleMolecular pain
dc.source.volume18
dc.source.beginpage17448069221089591
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States


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