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    Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress.

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    Author
    Li, Yue-Xin
    Li, Jia-Heng
    Guo, Yi
    Tao, Zhuo-Ying
    Qin, Shi-Hao
    Traub, Richard J
    An, Hong
    Cao, Dong-Yuan
    Date
    2022-04-21
    Journal
    Molecular Pain
    Publisher
    SAGE Publications Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1177%2F17448069221089591
    Abstract
    Oxytocin (OT) is recognized as a critical neuropeptide in pain-related disorders. Chronic pain caused by the comorbidity of temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) is common, but whether OT plays an analgesic role in the comorbidity of TMD and FMS is unknown. Female rats with masseter muscle inflammation combined with 3-day forced swim (FS) stress developed somatic hypersensitivity, which modeled the comorbidity of TMD and FMS. Using this model, the effects of spinal OT administration on mechanical allodynia and thermal hyperalgesia in hindpaws were examined. Furthermore, the protein levels of OT receptors and 5-HT2A receptors in the L4-L5 spinal dorsal horn were analyzed by Western blot. The OT receptor antagonist atosiban and 5-HT2A receptor antagonist ritanserin were intrathecally injected prior to OT injection in the separate groups. Intrathecal injection of 0.125 μg and 0.5 μg OT attenuated the hindpaw hyperalgesia. The expression of OT receptors and 5-HT2A receptors in the L4-L5 spinal dorsal horn significantly increased following intrathecal injection of 0.5 μg OT. Intrathecal administration of either the OT receptor antagonist atosiban or 5-HT2A receptor antagonist ritanserin blocked the analgesic effect of OT. These results suggest that OT may inhibit hindpaw hyperalgesia evoked by orofacial inflammation combined with stress through OT receptors and/or 5-HT2A receptors, thus providing a therapeutic prospect for drugs targeting the OT system and for patients with comorbidity of TMD and FMS.
    Keyword
    fibromyalgia syndrome
    oxytocin
    pain
    serotonin
    temporomandibular disorder
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18741
    ae974a485f413a2113503eed53cd6c53
    10.1177/17448069221089591
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