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    Relative Effectiveness of MF59 Adjuvanted Trivalent Influenza Vaccine vs Nonadjuvanted Vaccines During the 2019-2020 Influenza Season.

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    Author
    Imran, Mahrukh
    Puig-Barbera, Joan
    Ortiz, Justin R
    Fischer, Lauren
    O'Brien, Dan
    Bonafede, Machaon
    Mansi, James A
    Boikos, Constantina
    Date
    2022-04-02
    Journal
    Open Forum Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1093/ofid/ofac167
    Abstract
    This retrospective cohort study used electronic medical records linked to pharmacy and medical claims data. The study population included adults age ≥65 years with a record of aIIV3, IIV4e, or HD-IIV3 vaccination. A doubly robust inverse probability of treatment weighting model was used to derive adjusted odds ratios (ORs). rVE was calculated by (1 - ORadjusted)*100 and was determined overall and separately for age subgroups. An exploratory analysis evaluated the outcome separately in inpatient and outpatient settings.
    Rights/Terms
    © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
    Keyword
    adjuvanted influenza vaccine
    high-dose influenza vaccine
    older adults
    quadrivalent inactivated influenza vaccine
    relative vaccine effectiveness
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18728
    ae974a485f413a2113503eed53cd6c53
    10.1093/ofid/ofac167
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      Relative Vaccine Effectiveness of Adjuvanted Trivalent Influenza Vaccine over Three Consecutive Influenza Seasons in the United States.

      Boikos, Constantina; McGovern, Ian; Ortiz, Justin R; Puig-Barberà, Joan; Versage, Eve; Haag, Mendel (2022-09-02)
      Traditional influenza vaccines may be less immunogenic in adults ≥65 years of age due to immunosenescence. Two influenza vaccines-MF59®-adjuvanted trivalent inactivated influenza vaccine (aIIV3) and high-dose influenza vaccine (HD-IIV3)-were developed to overcome this problem. We summarize estimates of the relative vaccine effectiveness (rVE) of aIIV3 vs. HD-IIV3 and aIIV3 vs. standard, egg-based quadrivalent influenza vaccines (IIV4e) during the 2017-2018, 2018-2019, and 2019-2020 US influenza seasons using the same underlying electronic medical record and linked claims dataset for all three seasons. The primary outcome was influenza-related medical encounters (IRMEs), defined by diagnostic codes specific to influenza (ICD J09*-J11*). rVE was estimated using propensity score methods adjusting for demographics and health status. rVE estimates demonstrated consistent benefit for aIIV3 over IIV4e in the overall and at-risk populations. Relative to HD-IIV3, aIIV3 provided improved benefit in the overall study population and comparable benefit in the at-risk population across each season.
    • Thumbnail

      Review of Analyses Estimating Relative Vaccine Effectiveness of Cell-Based Quadrivalent Influenza Vaccine in Three Consecutive US Influenza Seasons.

      Boikos, Constantina; McGovern, Ian; Molrine, Deborah; Ortiz, Justin R; Puig-Barberà, Joan; Haag, Mendel (MDPI AG, 2022-06-03)
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    • Thumbnail

      Global influenza seasonality to inform country-level vaccine programs: An analysis of WHO FluNet influenza surveillance data between 2011 and 2016

      Newman, Laura (Laura P.), 1983-; Bhat, Niranjan; Fleming, Jessica Ann; Neuzil, Kathleen (PLOS One, 2018-02-21)
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