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    Prevention of Cardiovascular Events and Mortality With Icosapent Ethyl in Patients With Prior Myocardial Infarction.

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    Author
    Gaba, Prakriti
    Bhatt, Deepak L
    Steg, Ph Gabriel
    Miller, Michael
    Brinton, Eliot A
    Jacobson, Terry A
    Ketchum, Steven B
    Juliano, Rebecca A
    Jiao, Lixia
    Doyle, Ralph T
    Granowitz, Craig
    Tardif, Jean-Claude
    Giugliano, Robert P
    Martens, Fabrice M A C
    Gibson, C Michael
    Ballantyne, Christie M
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    Date
    2022-05-03
    Journal
    Journal of the American College of Cardiology
    Publisher
    Elsevier
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.jacc.2022.02.035
    Abstract
    BACKGROUND: REDUCE-IT was a double-blind trial that randomized 8,179 statin-treated patients with controlled low-density lipoprotein cholesterol and moderately elevated triglycerides to icosapent ethyl (IPE) or placebo. There was a significant reduction in the primary endpoint, including death from cardiovascular (CV) causes. The specific impact of IPE among patients with prior myocardial infarction (MI) was unknown. OBJECTIVES: Our goal was to examine the benefit of IPE on ischemic events among patients with prior MI in REDUCE-IT. METHODS: We performed post hoc analyses of patients with prior MI. The primary endpoint was CV death, MI, stroke, coronary revascularization, or hospitalization for unstable angina. The key secondary endpoint was CV death, MI, or stroke. RESULTS: A total of 3,693 patients had a history of prior MI. The primary endpoint was reduced from 26.1% to 20.2% with IPE vs placebo; HR: 0.74 (95% CI: 0.65-0.85; P = 0.00001). The key secondary endpoint was reduced from 18.0% to 13.3%; HR: 0.71 (95% CI: 0.61-0.84; P = 0.00006). There was also a significant 35% relative risk reduction in total ischemic events (P = 0.0000001), a 34% reduction in MI (P = 0.00009), a 30% reduction in CV death (P = 0.01), and a 20% lower rate of all-cause mortality (P = 0.054), although there was a slight increase in atrial fibrillation. Sudden cardiac death and cardiac arrest were also significantly reduced by 40% and 56%, respectively. CONCLUSIONS: Patients with a history of prior MI in REDUCE-IT treated with IPE demonstrated large and significant relative and absolute risk reductions in ischemic events, including CV death. (A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event. [REDUCE-IT]; NCT01492361).
    Rights/Terms
    Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
    Keyword
    clinical trials
    icosapent ethyl
    ischemic events
    myocardial infarction
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18724
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jacc.2022.02.035
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