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dc.contributor.authorLiu, Jin
dc.contributor.authorRuan, Jianping
dc.contributor.authorWeir, Michael D
dc.contributor.authorRen, Ke
dc.contributor.authorSchneider, Abraham
dc.contributor.authorWang, Ping
dc.contributor.authorOates, Thomas W
dc.contributor.authorChang, Xiaofeng
dc.contributor.authorXu, Hockin H K
dc.date.accessioned2022-04-27T16:48:09Z
dc.date.available2022-04-27T16:48:09Z
dc.date.issued2019-06-04
dc.identifier.urihttp://hdl.handle.net/10713/18686
dc.description.abstractPeriodontitis is a prevalent infectious disease worldwide, causing the damage of periodontal support tissues, which can eventually lead to tooth loss. The goal of periodontal treatment is to control the infections and reconstruct the structure and function of periodontal tissues including cementum, periodontal ligament (PDL) fibers, and bone. The regeneration of these three types of tissues, including the re-formation of the oriented PDL fibers to be attached firmly to the new cementum and alveolar bone, remains a major challenge. This article represents the first systematic review on the cutting-edge researches on the regeneration of all three types of periodontal tissues and the simultaneous regeneration of the entire bone-PDL-cementum complex, via stem cells, bio-printing, gene therapy, and layered bio-mimetic technologies. This article primarily includes bone regeneration; PDL regeneration; cementum regeneration; endogenous cell-homing and host-mobilized stem cells; 3D bio-printing and generation of the oriented PDL fibers; gene therapy-based approaches for periodontal regeneration; regenerating the bone-PDL-cementum complex via layered materials and cells. These novel developments in stem cell technology and bioactive and bio-mimetic scaffolds are highly promising to substantially enhance the periodontal regeneration including both hard and soft tissues, with applicability to other therapies in the oral and maxillofacial region. © 2019 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/cells8060537en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofCellsen_US
dc.subjectbone-PDL-cementumen_US
dc.subjectgrowth factorsen_US
dc.subjectperiodontal regenerationen_US
dc.subjectscaffoldsen_US
dc.subjectstem cellsen_US
dc.subjecttissue engineeringen_US
dc.titlePeriodontal Bone-Ligament-Cementum Regeneration via Scaffolds and Stem Cells.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cells8060537
dc.identifier.pmid31167434
dc.source.journaltitleCells
dc.source.volume8
dc.source.issue6
dc.source.countrySwitzerland


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