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    Periodontal Bone-Ligament-Cementum Regeneration via Scaffolds and Stem Cells.

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    Author
    Liu, Jin
    Ruan, Jianping
    Weir, Michael D
    Ren, Ke
    Schneider, Abraham
    Wang, Ping
    Oates, Thomas W
    Chang, Xiaofeng
    Xu, Hockin H K
    Date
    2019-06-04
    Journal
    Cells
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cells8060537
    Abstract
    Periodontitis is a prevalent infectious disease worldwide, causing the damage of periodontal support tissues, which can eventually lead to tooth loss. The goal of periodontal treatment is to control the infections and reconstruct the structure and function of periodontal tissues including cementum, periodontal ligament (PDL) fibers, and bone. The regeneration of these three types of tissues, including the re-formation of the oriented PDL fibers to be attached firmly to the new cementum and alveolar bone, remains a major challenge. This article represents the first systematic review on the cutting-edge researches on the regeneration of all three types of periodontal tissues and the simultaneous regeneration of the entire bone-PDL-cementum complex, via stem cells, bio-printing, gene therapy, and layered bio-mimetic technologies. This article primarily includes bone regeneration; PDL regeneration; cementum regeneration; endogenous cell-homing and host-mobilized stem cells; 3D bio-printing and generation of the oriented PDL fibers; gene therapy-based approaches for periodontal regeneration; regenerating the bone-PDL-cementum complex via layered materials and cells. These novel developments in stem cell technology and bioactive and bio-mimetic scaffolds are highly promising to substantially enhance the periodontal regeneration including both hard and soft tissues, with applicability to other therapies in the oral and maxillofacial region. © 2019 by the authors.
    Keyword
    bone-PDL-cementum
    growth factors
    periodontal regeneration
    scaffolds
    stem cells
    tissue engineering
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18686
    ae974a485f413a2113503eed53cd6c53
    10.3390/cells8060537
    Scopus Count
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