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dc.contributor.authorNarayanan, Shivakumar
dc.contributor.authorChua, Joel V
dc.contributor.authorBaddley, John W
dc.date.accessioned2022-04-27T13:17:05Z
dc.date.available2022-04-27T13:17:05Z
dc.date.issued2022-04-09
dc.identifier.urihttp://hdl.handle.net/10713/18681
dc.description.abstractThe severe surge of coronavirus disease 2019 (COVID-19) cases on the Indian subcontinent in early 2021 was marked by an unusually high number of COVID-19-associated mucormycosis (CAM) cases reported during this same period. This is significantly higher than predicted based on available data about prevalence and risk factors for this condition. This may be due to an unusual alignment of multiple risk factors for this condition. There is high background prevalence of mucormycosis in India likely from a high prevalence of risk factors, including undiagnosed or poorly controlled diabetes. COVID-19-induced immune dysregulation and immune suppression from steroid therapy increase the risk. The role of environmental exposure is unclear. System factors such as lack of access to healthcare during a pandemic may result in delayed diagnosis or suboptimal management with potentially poor outcomes. Here, we review currently identified risk factors and pathogenesis of CAM in a pandemic surge. © The Author(s) 2021.en_US
dc.description.urihttps://doi.org/10.1093/cid/ciab726en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofClinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of Americaen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.en_US
dc.subjectCOVID-19en_US
dc.subjectmucormycosisen_US
dc.subjectrhino-orbito-cerebralen_US
dc.subjectsteroid therapyen_US
dc.subjectzygomycosisen_US
dc.titleCoronavirus Disease 2019-Associated Mucormycosis: Risk Factors and Mechanisms of Disease.en_US
dc.typeArticleen_US
dc.identifier.doi10.1093/cid/ciab726
dc.identifier.pmid34420052
dc.source.journaltitleClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dc.source.volume74
dc.source.issue7
dc.source.beginpage1279
dc.source.endpage1283
dc.source.countryUnited States


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