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    Coronavirus Disease 2019-Associated Mucormycosis: Risk Factors and Mechanisms of Disease.

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    Author
    Narayanan, Shivakumar
    Chua, Joel V
    Baddley, John W
    Date
    2022-04-09
    Journal
    Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/cid/ciab726
    Abstract
    The severe surge of coronavirus disease 2019 (COVID-19) cases on the Indian subcontinent in early 2021 was marked by an unusually high number of COVID-19-associated mucormycosis (CAM) cases reported during this same period. This is significantly higher than predicted based on available data about prevalence and risk factors for this condition. This may be due to an unusual alignment of multiple risk factors for this condition. There is high background prevalence of mucormycosis in India likely from a high prevalence of risk factors, including undiagnosed or poorly controlled diabetes. COVID-19-induced immune dysregulation and immune suppression from steroid therapy increase the risk. The role of environmental exposure is unclear. System factors such as lack of access to healthcare during a pandemic may result in delayed diagnosis or suboptimal management with potentially poor outcomes. Here, we review currently identified risk factors and pathogenesis of CAM in a pandemic surge. © The Author(s) 2021.
    Rights/Terms
    © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
    Keyword
    COVID-19
    mucormycosis
    rhino-orbito-cerebral
    steroid therapy
    zygomycosis
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18681
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciab726
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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