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dc.contributor.authorHol, Haakon R
dc.contributor.authorFlak, Marianne M
dc.contributor.authorChang, Linda
dc.contributor.authorLøhaugen, Gro Christine Christensen
dc.contributor.authorBjuland, Knut Jørgen
dc.contributor.authorRimol, Lars M
dc.contributor.authorEngvig, Andreas
dc.contributor.authorSkranes, Jon
dc.contributor.authorErnst, Thomas
dc.contributor.authorMadsen, Bengt-Ove
dc.contributor.authorHernes, Susanne S
dc.date.accessioned2022-04-25T11:36:20Z
dc.date.available2022-04-25T11:36:20Z
dc.date.issued2022-04-04
dc.identifier.urihttp://hdl.handle.net/10713/18640
dc.description.abstractMagnetic resonance imaging acquisition at 1.5 T were performed at baseline, and after four- and 16-weeks post training. A total of 81 individuals with MCI accepted invitations to undergo 25 training sessions over 5 weeks. Longitudinal Linear Mixed effect models investigated the effect of adaptive vs. non-adaptive WM training. The LME model was fitted for each location (vertex). On all statistical analyzes, a threshold was applied to yield an expected false discovery rate (FDR) of 5%. A secondary LME model investigated the effects of LMX1A and APOE-ε4 on cortical thickness trajectories after WM training.en_US
dc.description.urihttps://doi.org/10.3389/fnagi.2022.796110en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Aging Neuroscienceen_US
dc.rightsCopyright © 2022 Hol, Flak, Chang, Løhaugen, Bjuland, Rimol, Engvig, Skranes, Ernst, Madsen and Hernes.en_US
dc.subjectAPOE genotypeen_US
dc.subjectLMX1Aen_US
dc.subjectMCIen_US
dc.subjectcortical thicknessen_US
dc.subjectworking memory trainingen_US
dc.titleCortical Thickness Changes After Computerized Working Memory Training in Patients With Mild Cognitive Impairment.en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fnagi.2022.796110
dc.identifier.pmid35444526
dc.source.journaltitleFrontiers in aging neuroscience
dc.source.volume14
dc.source.beginpage796110
dc.source.endpage
dc.source.countrySwitzerland


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