Cortical Thickness Changes After Computerized Working Memory Training in Patients With Mild Cognitive Impairment.
Author
Hol, Haakon RFlak, Marianne M
Chang, Linda
Løhaugen, Gro Christine Christensen
Bjuland, Knut Jørgen
Rimol, Lars M
Engvig, Andreas
Skranes, Jon
Ernst, Thomas
Madsen, Bengt-Ove
Hernes, Susanne S
Date
2022-04-04Journal
Frontiers in Aging NeurosciencePublisher
Frontiers Media S.A.Type
Article
Metadata
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Magnetic resonance imaging acquisition at 1.5 T were performed at baseline, and after four- and 16-weeks post training. A total of 81 individuals with MCI accepted invitations to undergo 25 training sessions over 5 weeks. Longitudinal Linear Mixed effect models investigated the effect of adaptive vs. non-adaptive WM training. The LME model was fitted for each location (vertex). On all statistical analyzes, a threshold was applied to yield an expected false discovery rate (FDR) of 5%. A secondary LME model investigated the effects of LMX1A and APOE-ε4 on cortical thickness trajectories after WM training.Rights/Terms
Copyright © 2022 Hol, Flak, Chang, Løhaugen, Bjuland, Rimol, Engvig, Skranes, Ernst, Madsen and Hernes.Identifier to cite or link to this item
http://hdl.handle.net/10713/18640ae974a485f413a2113503eed53cd6c53
10.3389/fnagi.2022.796110
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