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    Cortical Thickness Changes After Computerized Working Memory Training in Patients With Mild Cognitive Impairment.

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    Author
    Hol, Haakon R
    Flak, Marianne M
    Chang, Linda
    Løhaugen, Gro Christine Christensen
    Bjuland, Knut Jørgen
    Rimol, Lars M
    Engvig, Andreas
    Skranes, Jon
    Ernst, Thomas
    Madsen, Bengt-Ove
    Hernes, Susanne S
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    Date
    2022-04-04
    Journal
    Frontiers in Aging Neuroscience
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fnagi.2022.796110
    Abstract
    Magnetic resonance imaging acquisition at 1.5 T were performed at baseline, and after four- and 16-weeks post training. A total of 81 individuals with MCI accepted invitations to undergo 25 training sessions over 5 weeks. Longitudinal Linear Mixed effect models investigated the effect of adaptive vs. non-adaptive WM training. The LME model was fitted for each location (vertex). On all statistical analyzes, a threshold was applied to yield an expected false discovery rate (FDR) of 5%. A secondary LME model investigated the effects of LMX1A and APOE-ε4 on cortical thickness trajectories after WM training.
    Rights/Terms
    Copyright © 2022 Hol, Flak, Chang, Løhaugen, Bjuland, Rimol, Engvig, Skranes, Ernst, Madsen and Hernes.
    Keyword
    APOE genotype
    LMX1A
    MCI
    cortical thickness
    working memory training
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18640
    ae974a485f413a2113503eed53cd6c53
    10.3389/fnagi.2022.796110
    Scopus Count
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