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dc.contributor.authorAkalin, Enver
dc.contributor.authorWeir, Matthew R
dc.contributor.authorBunnapradist, Suphamai
dc.contributor.authorBrennan, Daniel C
dc.contributor.authorDelos Santos, Rowena
dc.contributor.authorLangone, Anthony
dc.contributor.authorDjamali, Arjang
dc.contributor.authorXu, Hua
dc.contributor.authorJin, Xia
dc.contributor.authorDholakia, Sham
dc.contributor.authorWoodward, Robert N
dc.contributor.authorBromberg, Jonathan S
dc.date.accessioned2022-04-18T15:16:32Z
dc.date.available2022-04-18T15:16:32Z
dc.date.issued2021-09-28
dc.identifier.urihttp://hdl.handle.net/10713/18601
dc.description.abstractAlloMap Kidney classifier scores in the primary validation set differed significantly between quiescence (median, 9.49; IQR, 7.68-11.53) and rejection (median, 13.09; IQR, 11.25-15.28), with P<0.001. In the second validation set, the cohorts were statistically different (P=0.03) and the medians were similar to the primary validation set. The AUC for discriminating rejection from quiescence was 0.786 for the primary validation and 0.800 for the second validation. AlloMap Kidney results were not significantly correlated with AlloSure, although both were elevated in rejection. The ability to discriminate rejection from quiescence was improved when AlloSure and AlloMap Kidney were used together (AUC, 0.894).en_US
dc.description.urihttps://doi.org/10.34067/KID.0005062021en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Nephrologyen_US
dc.relation.ispartofKidney360en_US
dc.rightsCopyright © 2021 by the American Society of Nephrology.en_US
dc.subjectT cell-mediated rejectionen_US
dc.subjectallograft rejectionen_US
dc.subjectantibody-mediated rejectionen_US
dc.subjectdonor-derived cell-free DNAen_US
dc.subjectgene expression profilingen_US
dc.subjectkidney transplantationen_US
dc.subjecttransplantationen_US
dc.titleClinical Validation of an Immune Quiescence Gene Expression Signature in Kidney Transplantation.en_US
dc.typeArticleen_US
dc.identifier.doi10.34067/KID.0005062021
dc.identifier.pmid35419538
dc.source.journaltitleKidney360
dc.source.volume2
dc.source.issue12
dc.source.beginpage1998
dc.source.endpage2009
dc.source.countryUnited States


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