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dc.contributor.authorBellon, Alfredo
dc.contributor.authorFeuillet, Vincent
dc.contributor.authorCortez-Resendiz, Alonso
dc.contributor.authorMouaffak, Faycal
dc.contributor.authorKong, Lan
dc.contributor.authorHong, L Elliot
dc.contributor.authorDe Godoy, Lilian
dc.contributor.authorJay, Therese M
dc.contributor.authorHosmalin, Anne
dc.contributor.authorKrebs, Marie-Odile
dc.date.accessioned2022-04-14T14:50:08Z
dc.date.available2022-04-14T14:50:08Z
dc.date.issued2022-04-01
dc.identifier.urihttp://hdl.handle.net/10713/18573
dc.description.abstractThe long lapse between the presumptive origin of schizophrenia (SCZ) during early development and its diagnosis in late adolescence has hindered the study of crucial neurodevelopmental processes directly in living patients. Dopamine, a neurotransmitter consistently associated with the pathophysiology of SCZ, participates in several aspects of brain development including pruning of neuronal extensions. Excessive pruning is considered the cause of the most consistent finding in SCZ, namely decreased brain volume. It is therefore possible that patients with SCZ carry an increased susceptibility to dopamine’s pruning effects and that this susceptibility would be more obvious in the early stages of neuronal development when dopamine pruning effects appear to be more prominent. Obtaining developing neurons from living patients is not feasible. Instead, we used Monocyte-Derived-Neuronal-like Cells (MDNCs) as these cells can be generated in only 20 days and deliver reproducible results. In this study, we expanded the number of individuals in whom we tested the reproducibility of MDNCs. We also deepened the characterization of MDNCs by comparing its neurostructure to that of human developing neurons. Moreover, we studied MDNCs from 12 controls and 13 patients with SCZ. Patients’ cells differentiate more efficiently, extend longer secondary neurites and grow more primary neurites. In addition, MDNCs from medicated patients expresses less D1R and prune more primary neurites when exposed to dopamine. Haloperidol did not influence our results but the role of other antipsychotics was not examined and thus, needs to be considered as a confounder. © 2022, The Author(s).en_US
dc.description.urihttps://doi.org/10.1038/s41380-022-01514-wen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.rights© 2022. The Author(s).en_US
dc.titleDopamine-induced pruning in monocyte-derived-neuronal-like cells (MDNCs) from patients with schizophrenia.en_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41380-022-01514-w
dc.identifier.pmid35365810
dc.source.journaltitleMolecular psychiatry
dc.source.countryEngland


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