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    Functional and structural modifications of influenza antibodies during pregnancy

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    Author
    Jennewein, Madeleine F.
    Kosikova, Martina
    Noelette, Francesca J.
    Radvak, Peter
    Boudreau, Carolyn M.
    Campbell, James D.
    Chen, Wilbur H.
    Xie, Hang
    Alter, Galit
    Pasetti, Marcela F.
    Date
    2022-04-15
    Journal
    iScience
    Publisher
    Elsevier
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.isci.2022.104088
    Abstract
    Pregnancy represents a unique tolerogenic immune state which may alter susceptibility to infection and vaccine response. Here, we characterized humoral immunity to seasonal influenza vaccine strains in pregnant and non-pregnant women. Although serological responses to influenza remained largely intact during late pregnancy, distinct modifications were observed. Pregnant women had reduced hemagglutinin subtype-1 (H1)- IgG, IgG1, IgG2, and IgG3, hemagglutination inhibition, and group 1 and 2 stem IgG titers. Intriguingly, H1-specific avidity and FcγR1 binding increased, and influenza antibodies had distinct Fc and Fab glycans characterized by increased di-galactosylation and di-sialylation. H1-specific Fc-functionality (i.e. monocyte phagocytosis and complement deposition) was moderately reduced in pregnancy. Multivariate antibody analysis revealed two distinct populations (pregnant vs. non-pregnant) segregated by H1 FcγR1 binding, H1-IgG levels, and Fab and Fc glycosylation. Our results demonstrated a structural and functional modulation of influenza humoral immunity during pregnancy that was antigen-specific and consistent with reduced inflammation and efficient placental transport © 2022 The Authors
    Sponsors
    National Institutes of Health
    Keyword
    Pregnancy
    Virology
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18533
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.isci.2022.104088
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