Functional and structural modifications of influenza antibodies during pregnancy
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Author
Jennewein, Madeleine F.Kosikova, Martina
Noelette, Francesca J.
Radvak, Peter
Boudreau, Carolyn M.
Campbell, James D.
Chen, Wilbur H.
Xie, Hang
Alter, Galit
Pasetti, Marcela F.
Date
2022-04-15Journal
iSciencePublisher
ElsevierType
Article
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Pregnancy represents a unique tolerogenic immune state which may alter susceptibility to infection and vaccine response. Here, we characterized humoral immunity to seasonal influenza vaccine strains in pregnant and non-pregnant women. Although serological responses to influenza remained largely intact during late pregnancy, distinct modifications were observed. Pregnant women had reduced hemagglutinin subtype-1 (H1)- IgG, IgG1, IgG2, and IgG3, hemagglutination inhibition, and group 1 and 2 stem IgG titers. Intriguingly, H1-specific avidity and FcγR1 binding increased, and influenza antibodies had distinct Fc and Fab glycans characterized by increased di-galactosylation and di-sialylation. H1-specific Fc-functionality (i.e. monocyte phagocytosis and complement deposition) was moderately reduced in pregnancy. Multivariate antibody analysis revealed two distinct populations (pregnant vs. non-pregnant) segregated by H1 FcγR1 binding, H1-IgG levels, and Fab and Fc glycosylation. Our results demonstrated a structural and functional modulation of influenza humoral immunity during pregnancy that was antigen-specific and consistent with reduced inflammation and efficient placental transport © 2022 The AuthorsSponsors
National Institutes of HealthIdentifier to cite or link to this item
http://hdl.handle.net/10713/18533ae974a485f413a2113503eed53cd6c53
10.1016/j.isci.2022.104088