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A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma

dc.contributor.authorWu, Shijia
dc.contributor.authorAi, Yong
dc.contributor.authorHuang, Huimin
dc.contributor.authorWu, Guangyu
dc.contributor.authorZhou, Shipeng
dc.contributor.authorHong, Weilong
dc.contributor.authorAkuetteh, Percy David Papa
dc.contributor.authorJin, Guihua
dc.contributor.authorZhao, Xingling
dc.contributor.authorZhang, Yihua
dc.contributor.authorZhang, Xiaolong
dc.contributor.authorLan, Linhua
dc.date.accessioned2022-04-11T15:44:42Z
dc.date.available2022-04-11T15:44:42Z
dc.date.issued2022-04-02
dc.identifier.urihttp://hdl.handle.net/10713/18530
dc.description.abstractPancreatic adenocarcinoma (PAAD) is a severe malignant with a 5-year survival rate of approximately 9%. Oleanolic acid is a well-known natural triterpenoid which exhibits pharmacological activities. We previously synthesized a series of oleanolic acid derivatives and evaluated the tumor-suppressive activity of olean-28,13β-lactam (B28) in prostate cancer. However, the detailed mechanism remains to be understood.en_US
dc.description.urihttps://doi.org/10.1186/s12935-022-02562-6en_US
dc.language.isoenen_US
dc.relation.ispartofCancer Cell Internationalen_US
dc.rights© 2022. The Author(s).en_US
dc.subjectYTHDF1en_US
dc.subjectredox homeostasisen_US
dc.subjectmetabolic crisisen_US
dc.subjectglutaminolysisen_US
dc.subject.meshOleanolic Aciden_US
dc.titleA synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12935-022-02562-6
dc.identifier.pmid35366902
dc.source.journaltitleCancer cell international
dc.source.volume22
dc.source.issue1
dc.source.beginpage143
dc.source.endpage
dc.source.countryEngland


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