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    Impact of Bacterial Phenotypic Variation with Bacteriophage therapy: A Pilot Study with Prosthetic Joint Infection Isolates.

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    Author
    Doub, James B
    Urish, Ken
    Lee, Martin
    Fackler, Joseph
    Date
    2022-03-21
    Journal
    International Journal of Infectious Diseases : IJID
    Publisher
    Elsevier
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1016/j.ijid.2022.03.022
    Abstract
    Background: Given the specificity of bacteriophage attachment receptors, a single bacterial isolate is currently utilized to match to a bacteriophage therapeutic thereby extrapolating activity to all bacteria in vivo. Obstinately, the main bacteriophage attachment receptor for Staphylococcus aureus is teichoic acid and it is known that this receptor has phenotypic variations in different in vivo environments. Consequently, the aim of this study was to determine if bacteriophage activity is similar across all in vivo prosthetic joint infection environments. Methods: Three patients with prosthetic joint infections who had S. aureus grow from arthrocentesis cultures and at least three deep tissue cultures were analyzed for growth inhibition with a library of 56 bacteriophages RESULTS: Discordant bacteriophage activity was seen across the different in vivo environments. As well bacteriophages with the most robust lytic potential to the arthrocentesis isolates usually did not have activity to all the deep tissues clinical isolates. Conclusion: Variations of bacteriophage activity can occur between the different in vivo clinical environments which is likely secondary to different glycosylation patterns of teichoic acid. Consequently, if discordant activity is present then retreating with bacteriophages that have activity is likely needed for effective, reproducible outcomes.
    Rights/Terms
    Copyright © 2022. Published by Elsevier Ltd.
    Keyword
    Attachment receptors, Staphylococcus
    Bacteriophage therapy
    Phenotypic variation
    Prosthetic joint infections
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18508
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijid.2022.03.022
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