Accounting for Serial and Parallel Functionality of the Lung May Minimize Post-Radiotherapy Loss of Respiratory Function in Lung Cancer Patients
dc.contributor.author | Vicente, E.M. | |
dc.contributor.author | Modiri, A. | |
dc.contributor.author | Kipritidis, J. | |
dc.contributor.author | Hagan, A. | |
dc.contributor.author | Yu, K.C. | |
dc.contributor.author | Yan, Y. | |
dc.contributor.author | Owen, D.R. | |
dc.contributor.author | Matuszak, M.M. | |
dc.contributor.author | Mohindra, P. | |
dc.contributor.author | Sun, K. | |
dc.contributor.author | Timmerman, R.D. | |
dc.contributor.author | Sawant, A. | |
dc.date.accessioned | 2022-04-06T15:26:58Z | |
dc.date.available | 2022-04-06T15:26:58Z | |
dc.date.issued | 2021-11 | |
dc.identifier.uri | http://hdl.handle.net/10713/18482 | |
dc.description.abstract | Functional lung avoidance (FLA) radiotherapy (RT) aims to minimize post-RT respiratory function loss. Current FLA approaches spatially map lung function and preferentially avoid dose to high-functioning lung (HFL). However, current FLA methods do not adequately consider the conducting architecture responsible for gas exchange (airways/vasculature). Previously, we showed that excessive toxicity to airways results in airway collapse, leading to functional loss within downstream lung sub-volumes. We proposed the functionally weighted airway sparing (FWAS) method to spare airways connected to HFL. Here, we propose a novel method that combines both FLA and FWAS to minimize post-RT functional loss. | en_US |
dc.description.uri | https://doi.org/10.1016/j.ijrobp.2021.07.138 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | International Journal of Radiation Oncology - Biology - Physics | en_US |
dc.rights | Copyright © 2021 Published by Elsevier Inc. | en_US |
dc.rights.uri | https://www.elsevier.com/tdm/userlicense/1.0/ | |
dc.title | Accounting for Serial and Parallel Functionality of the Lung May Minimize Post-Radiotherapy Loss of Respiratory Function in Lung Cancer Patients | en_US |
dc.type | Abstract | en_US |
dc.identifier.doi | 10.1016/j.ijrobp.2021.07.138 | |
dc.source.journaltitle | International Journal of Radiation Oncology*Biology*Physics | |
dc.source.volume | 111 | |
dc.source.issue | 3 | |
dc.source.beginpage | S53 |