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dc.contributor.authorVicente, E.M.
dc.contributor.authorModiri, A.
dc.contributor.authorKipritidis, J.
dc.contributor.authorHagan, A.
dc.contributor.authorYu, K.C.
dc.contributor.authorYan, Y.
dc.contributor.authorOwen, D.R.
dc.contributor.authorMatuszak, M.M.
dc.contributor.authorMohindra, P.
dc.contributor.authorSun, K.
dc.contributor.authorTimmerman, R.D.
dc.contributor.authorSawant, A.
dc.date.accessioned2022-04-06T15:26:58Z
dc.date.available2022-04-06T15:26:58Z
dc.date.issued2021-11
dc.identifier.urihttp://hdl.handle.net/10713/18482
dc.description.abstractFunctional lung avoidance (FLA) radiotherapy (RT) aims to minimize post-RT respiratory function loss. Current FLA approaches spatially map lung function and preferentially avoid dose to high-functioning lung (HFL). However, current FLA methods do not adequately consider the conducting architecture responsible for gas exchange (airways/vasculature). Previously, we showed that excessive toxicity to airways results in airway collapse, leading to functional loss within downstream lung sub-volumes. We proposed the functionally weighted airway sparing (FWAS) method to spare airways connected to HFL. Here, we propose a novel method that combines both FLA and FWAS to minimize post-RT functional loss.en_US
dc.description.urihttps://doi.org/10.1016/j.ijrobp.2021.07.138en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_US
dc.rightsCopyright © 2021 Published by Elsevier Inc.en_US
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.titleAccounting for Serial and Parallel Functionality of the Lung May Minimize Post-Radiotherapy Loss of Respiratory Function in Lung Cancer Patientsen_US
dc.typeAbstracten_US
dc.identifier.doi10.1016/j.ijrobp.2021.07.138
dc.source.journaltitleInternational Journal of Radiation Oncology*Biology*Physics
dc.source.volume111
dc.source.issue3
dc.source.beginpageS53


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