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    Accounting for Serial and Parallel Functionality of the Lung May Minimize Post-Radiotherapy Loss of Respiratory Function in Lung Cancer Patients

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    Author
    Vicente, E.M.
    Modiri, A.
    Kipritidis, J.
    Hagan, A.
    Yu, K.C.
    Yan, Y.
    Owen, D.R.
    Matuszak, M.M.
    Mohindra, P.
    Sun, K.
    Timmerman, R.D.
    Sawant, A.
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    Date
    2021-11
    Journal
    International Journal of Radiation Oncology - Biology - Physics
    Publisher
    Elsevier
    Type
    Abstract
    
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    See at
    https://doi.org/10.1016/j.ijrobp.2021.07.138
    Abstract
    Functional lung avoidance (FLA) radiotherapy (RT) aims to minimize post-RT respiratory function loss. Current FLA approaches spatially map lung function and preferentially avoid dose to high-functioning lung (HFL). However, current FLA methods do not adequately consider the conducting architecture responsible for gas exchange (airways/vasculature). Previously, we showed that excessive toxicity to airways results in airway collapse, leading to functional loss within downstream lung sub-volumes. We proposed the functionally weighted airway sparing (FWAS) method to spare airways connected to HFL. Here, we propose a novel method that combines both FLA and FWAS to minimize post-RT functional loss.
    Rights/Terms
    Copyright © 2021 Published by Elsevier Inc.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18482
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijrobp.2021.07.138
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