Accounting for Serial and Parallel Functionality of the Lung May Minimize Post-Radiotherapy Loss of Respiratory Function in Lung Cancer Patients
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Author
Vicente, E.M.Modiri, A.
Kipritidis, J.
Hagan, A.
Yu, K.C.
Yan, Y.
Owen, D.R.
Matuszak, M.M.
Mohindra, P.
Sun, K.
Timmerman, R.D.
Sawant, A.
Date
2021-11Journal
International Journal of Radiation Oncology - Biology - PhysicsPublisher
ElsevierType
Abstract
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Functional lung avoidance (FLA) radiotherapy (RT) aims to minimize post-RT respiratory function loss. Current FLA approaches spatially map lung function and preferentially avoid dose to high-functioning lung (HFL). However, current FLA methods do not adequately consider the conducting architecture responsible for gas exchange (airways/vasculature). Previously, we showed that excessive toxicity to airways results in airway collapse, leading to functional loss within downstream lung sub-volumes. We proposed the functionally weighted airway sparing (FWAS) method to spare airways connected to HFL. Here, we propose a novel method that combines both FLA and FWAS to minimize post-RT functional loss.Rights/Terms
Copyright © 2021 Published by Elsevier Inc.Identifier to cite or link to this item
http://hdl.handle.net/10713/18482ae974a485f413a2113503eed53cd6c53
10.1016/j.ijrobp.2021.07.138