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dc.contributor.authorBentefour, E.H.
dc.contributor.authorSawant, A.
dc.contributor.authorMossahebi, S.
dc.date.accessioned2022-04-06T15:23:10Z
dc.date.available2022-04-06T15:23:10Z
dc.date.issued2021-11
dc.identifier.urihttp://hdl.handle.net/10713/18479
dc.description.abstractThe lifetime of hydroxyl radicals, which cause radiobiological damage, is estimated to be a few microseconds. This time is much shorter than the actual spot-to-spot scanning time in proton pencil beam scanning (PBS) delivery (> 10 milliseconds). This mismatch in timescales becomes problematic in the case of FLASH treatment using PBS. Given that the FLASH effect is a spatially local and temporally finite phenomenon, it will be more accurate to evaluate it based on the spatial dose rate in Gy/sec/ cm3. Thus, delivering high doses at FLASH dose rates using PBS could be harmful to healthy tissues irradiated by the non-FLASH dose rate. In this study, we evaluate the extent of the healthy tissues that can be exposed to non-FLASH dose as well as the quantification of the received non-FLASH doses.en_US
dc.description.urihttps://doi.org/10.1016/j.ijrobp.2021.07.100en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_US
dc.rightsCopyright © 2021 Published by Elsevier Inc.en_US
dc.rights.urihttps://www.elsevier.com/tdm/userlicense/1.0/
dc.titleDosimetric Impact of Dose Rate Fall-Off in FLASH Proton Pencil Beam Scanning Treatmenten_US
dc.typeAbstracten_US
dc.identifier.doi10.1016/j.ijrobp.2021.07.100
dc.source.journaltitleInternational Journal of Radiation Oncology*Biology*Physics
dc.source.volume111
dc.source.issue3
dc.source.beginpageS32
dc.source.endpageS33


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