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    Dosimetric Impact of Dose Rate Fall-Off in FLASH Proton Pencil Beam Scanning Treatment

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    Author
    Bentefour, E.H.
    Sawant, A.
    Mossahebi, S.
    Date
    2021-11
    Journal
    International Journal of Radiation Oncology - Biology - Physics
    Publisher
    Elsevier
    Type
    Abstract
    
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    See at
    https://doi.org/10.1016/j.ijrobp.2021.07.100
    Abstract
    The lifetime of hydroxyl radicals, which cause radiobiological damage, is estimated to be a few microseconds. This time is much shorter than the actual spot-to-spot scanning time in proton pencil beam scanning (PBS) delivery (> 10 milliseconds). This mismatch in timescales becomes problematic in the case of FLASH treatment using PBS. Given that the FLASH effect is a spatially local and temporally finite phenomenon, it will be more accurate to evaluate it based on the spatial dose rate in Gy/sec/ cm3. Thus, delivering high doses at FLASH dose rates using PBS could be harmful to healthy tissues irradiated by the non-FLASH dose rate. In this study, we evaluate the extent of the healthy tissues that can be exposed to non-FLASH dose as well as the quantification of the received non-FLASH doses.
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    Copyright © 2021 Published by Elsevier Inc.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18479
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijrobp.2021.07.100
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