Dosimetric Impact of Dose Rate Fall-Off in FLASH Proton Pencil Beam Scanning Treatment
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2021-11Journal
International Journal of Radiation Oncology - Biology - PhysicsPublisher
ElsevierType
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The lifetime of hydroxyl radicals, which cause radiobiological damage, is estimated to be a few microseconds. This time is much shorter than the actual spot-to-spot scanning time in proton pencil beam scanning (PBS) delivery (> 10 milliseconds). This mismatch in timescales becomes problematic in the case of FLASH treatment using PBS. Given that the FLASH effect is a spatially local and temporally finite phenomenon, it will be more accurate to evaluate it based on the spatial dose rate in Gy/sec/ cm3. Thus, delivering high doses at FLASH dose rates using PBS could be harmful to healthy tissues irradiated by the non-FLASH dose rate. In this study, we evaluate the extent of the healthy tissues that can be exposed to non-FLASH dose as well as the quantification of the received non-FLASH doses.Rights/Terms
Copyright © 2021 Published by Elsevier Inc.Identifier to cite or link to this item
http://hdl.handle.net/10713/18479ae974a485f413a2113503eed53cd6c53
10.1016/j.ijrobp.2021.07.100