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    Prevalence and prognosis of increased pancreatic enzymes in patients with COVID-19: A systematic review and meta-analysis.

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    Author
    Yang, Feng
    Xu, Yecheng
    Dong, Yinlei
    Huang, Yuting
    Fu, Yunting
    Li, Tian
    Sun, Chenyu
    Pandanaboyana, Sanjay
    Windsor, John A
    Fu, Deliang
    Date
    2022-03-25
    Journal
    Pancreatology
    Publisher
    Elsevier
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.pan.2022.03.014
    https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35361531/
    Abstract
    Introduction: The prevalence of increased pancreatic enzymes (elevated serum amylase and/or lipase) and its relationship to clinical outcomes in patients with coronavirus disease 2019 (COVID-19) infection is not known. Methods: A systematic review and meta-analysis of relevant studies reporting prevalence and impact of increased pancreatic enzymes (defined as an elevation in amylase and/or lipase levels above the upper limit of normal [ULN] value) in COVID-19 was undertaken. Results: A total of 36,496 patients from 21 studies were included for this meta-analysis. The overall prevalence and mortality for increased pancreatic enzymes (>ULN) in COVID-19 were 25.4% (95% CI, 15.8%-36.2%) and 34.6% (95% CI, 25.5%-44.4%), respectively. The overall prevalence and mortality for increased pancreatic enzymes (>3 × ULN) were 6.1% (95% CI, 3.6%-9.2%) and 39.2% (95% CI, 18.7%-61.6%), respectively. Patients with increased pancreatic enzymes, including elevated serum lipase or amylase of either type, had worse clinical outcomes, including need for ICU admission, mechanical ventilation and mortality. Discussion: Increased pancreatic enzymes is frequent and may exacerbate the consequences of COVID-19 infection.
    Rights/Terms
    Copyright © 2022 IAP and EPC. Published by Elsevier B.V. All rights reserved.
    Keyword
    Amylase
    COVID-19
    Lipase
    Prevalence
    Prognosis
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18445
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pan.2022.03.014
    Scopus Count
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    UMB Coronavirus Publications
    UMB Open Access Articles

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