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dc.contributor.authorGraham, Susan M
dc.contributor.authorNance, Robin M
dc.contributor.authorChen, Junmei
dc.contributor.authorLe, Jennie
dc.contributor.authorChung, Dominic W
dc.contributor.authorWurfel, Mark M
dc.contributor.authorTirschwell, David L
dc.contributor.authorZunt, Joseph R
dc.contributor.authorMarra, Christina M
dc.contributor.authorHo, Emily L
dc.contributor.authorHuffer, Andrew
dc.contributor.authorChow, Felicia C
dc.contributor.authorMartin, Jeffrey N
dc.contributor.authorRyan, Alice S
dc.contributor.authorCrane, Heidi M
dc.contributor.authorLópez, José A
dc.contributor.authorLiles, W Conrad
dc.date.accessioned2022-03-31T12:10:35Z
dc.date.available2022-03-31T12:10:35Z
dc.date.issued2021-10-21
dc.identifier.urihttp://hdl.handle.net/10713/18416
dc.description.abstractAfter adjustment for age and sex, higher plasma viral load and higher angiopoeitin-2, soluble CD14, and VWF were associated with increased odds of ischemic stroke; higher nadir CD4 count was associated with decreased odds of ischemic stroke. VWF remained associated with subsequent ischemic stroke after adjustment for ASCVD score (adjusted odds, 1.74; 95% CI, 1.01-2.98 per log2 increment). In a separate model adjusting for VACS score, only VWF (adjusted odds, 1.80; 95% CI, 1.04-3.12 per log2 increment) was associated with subsequent ischemic stroke. In a sensitivity analysis excluding participants with viral load ≥400 copies/mL, associations between VWF and ischemic stroke were attenuated, with risk estimates ranging from 1.59 to 1.64 per log2 increment.en_US
dc.description.urihttps://doi.org/10.1093/ofid/ofab521en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofOpen Forum Infectious Diseasesen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.en_US
dc.subjectHIV infectionen_US
dc.subjectendothelial activationen_US
dc.subjecthemostasis/thrombosisen_US
dc.subjectischemic strokeen_US
dc.subjectvon Willebrand factoren_US
dc.titleElevated Plasma von Willebrand Factor Levels Are Associated With Subsequent Ischemic Stroke in Persons With Treated HIV Infection.en_US
dc.typeArticleen_US
dc.identifier.doi10.1093/ofid/ofab521
dc.identifier.pmid35350814
dc.source.journaltitleOpen forum infectious diseases
dc.source.volume8
dc.source.issue11
dc.source.beginpageofab521
dc.source.endpage
dc.source.countryUnited States


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