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dc.contributor.authorPan, Shujuan
dc.contributor.authorZhou, Yanfang
dc.contributor.authorYan, Ling
dc.contributor.authorXuan, Fangling
dc.contributor.authorTong, Jinghui
dc.contributor.authorLi, Yanli
dc.contributor.authorHuang, Junchao
dc.contributor.authorFeng, Wei
dc.contributor.authorChen, Song
dc.contributor.authorCui, Yimin
dc.contributor.authorYang, Fude
dc.contributor.authorTan, Shuping
dc.contributor.authorWang, Zhiren
dc.contributor.authorTian, Baopeng
dc.contributor.authorHong, L Elliot
dc.contributor.authorTan, Yun-Long
dc.contributor.authorTian, Li
dc.date.accessioned2022-03-31T12:00:23Z
dc.date.available2022-03-31T12:00:23Z
dc.date.issued2022-03-17
dc.identifier.urihttp://hdl.handle.net/10713/18413
dc.description.abstractIn this study, we recruited patients with first-episode schizophrenia (n = 75, average illness duration 12.3 months, average medication period 0.6 days) and healthy controls (n = 44) of both sexes. We first conducted whole-blood RNA sequencing to detect differentially expressed genes. We also explored transcriptomic data on the dorsal lateral prefrontal cortices (dlPFC) retrieved from the CommonMind Consortium for gene functional clustering; we measured plasma transforming growth factor β1 (TGF-β1) levels by enzyme-linked immunosorbent assay; we acquired high-resolution T 1-weighted MRI data on cortical thickness MRI; and we assessed cognitive function using the validated Chinese version of the MATRICS Consensus Cognitive Battery. We compared these parameters in patients with schizophrenia and controls, and analyzed their associations.en_US
dc.description.urihttps://doi.org/10.1503/jpn.210121en_US
dc.language.isoenen_US
dc.publisherCanadian Medical Association/Association Medical Canadienneen_US
dc.relation.ispartofJournal of Psychiatry & Neuroscience : JPNen_US
dc.rights© 2022 CMA Impact Inc. or its licensors.en_US
dc.titleTGF-β1 is associated with deficits in cognition and cerebral cortical thickness in first-episode schizophrenia.en_US
dc.typeArticleen_US
dc.identifier.doi10.1503/jpn.210121
dc.identifier.pmid35301253
dc.source.journaltitleJournal of psychiatry & neuroscience : JPN
dc.source.volume47
dc.source.issue2
dc.source.beginpageE86
dc.source.endpageE98
dc.source.countryCanada


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