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dc.contributor.authorTibbs, Ellis
dc.contributor.authorCao, Xuefang
dc.date.accessioned2022-03-28T13:15:20Z
dc.date.available2022-03-28T13:15:20Z
dc.date.issued2022-03-10
dc.identifier.urihttp://hdl.handle.net/10713/18380
dc.description.abstractThe Granzyme (Gzm) family has classically been recognized as a cytotoxic tool utilized by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells to illicit cell death to infected and cancerous cells. Their importance is established based on evidence showing that deficiencies in these cell death executors result in defective immune responses. Recent findings have shown the importance of Granzyme B (GzmB) in regulatory immune cells, which may contribute to tumor growth and immune evasion during cancer development. Other studies have shown that members of the Gzm family are important for biological processes such as extracellular matrix remodeling, angiogenesis and organized vascular degradation. With this growing body of evidence, it is becoming more important to understand the broader function of Gzm's rather than a specific executor of cell death, and we should be aware of the many alternative roles that Gzm's play in physiological and pathological conditions. Therefore, we review the classical as well as novel non-canonical functions of GzmB and discuss approaches to utilize these new findings to address current gaps in our understanding of the immune system and tissue development.en_US
dc.description.urihttps://doi.org/10.3390/cancers14061436en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofCancersen_US
dc.subjectGranzyme Ben_US
dc.subjectcanceren_US
dc.subjectcytotoxicityen_US
dc.subjectextracellular matrix remodelingen_US
dc.subjectimmune responseen_US
dc.subjecttissue developmenten_US
dc.titleEmerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cancers14061436
dc.identifier.pmid35326588
dc.source.journaltitleCancers
dc.source.volume14
dc.source.issue6
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countrySwitzerland


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