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    Antibody response after a booster dose of SARS-CoV-2 vaccine in liver transplant recipients and those with chronic liver diseases.

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    Author
    Chauhan, Mahak
    Nzeako, Ihechiluru
    Li, Feng
    Thuluvath, Paul J
    Date
    2022-03-22
    Journal
    Annals of Hepatology
    Publisher
    Elsevier
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.aohep.2022.100702
    Abstract
    Background &Aims: Lower antibody (Ab) responses after SARS-CoV-2 vaccination have been reported in liver transplant (LT) recipients and those with chronic liver diseases (CLD). The role of a booster dose in those with poor responses to initial vaccination is not well defined. Methods: In this prospective study, we determined antibody (Ab) response to spike protein after a booster dose in LT recipients and those with chronic liver diseases (CLD) with and without cirrhosis after they had a poor response to an initial standard regimen. Results: Of the 80 patients enrolled, 45 had LT, and 35 had CLD (18 with cirrhosis). A booster dose was given at a median of 138.5 days after the completion of the standard regimen. After the booster dose, 58 (73%, 31 LT, 27 CLD) had good response (≥250 U/mL), and 22 (28%, 14 LT, and 8 CLD) had poor response (7 undetectable and 15 with low Ab levels). No patient had any serious adverse events. The antibody responses were lower in those who had undetectable Ab (80 U/mL) than those who had low levels of Ab (0.80-249 U/mL) after the standard vaccination regimen (42% vs.87%, p=0.0001). The antibody responses after homologous and heterologous booster doses were similar. Conclusions: We have shown that a booster dose will enhance Ab responses in LT recipients and those with CLD who had poor responses after an initial vaccine regimen.
    Rights/Terms
    Copyright © 2022. Published by Elsevier España, S.L.U.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18375
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.aohep.2022.100702
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    UMB Coronavirus Publications
    UMB Open Access Articles

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