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dc.contributor.authorLee, Youri
dc.contributor.authorGrubbs, Gabrielle
dc.contributor.authorRamelli, Sabrina C
dc.contributor.authorLevine, Andrea R
dc.contributor.authorBathula, Allison
dc.contributor.authorSaharia, Kapil
dc.contributor.authorPurcell, Madeleine
dc.contributor.authorSingireddy, Shreya
dc.contributor.authorDugan, Colleen L
dc.contributor.authorKirchoff, Lindsey
dc.contributor.authorLankford, Allison
dc.contributor.authorCipriano, Sarah
dc.contributor.authorCurto, Ryan A
dc.contributor.authorWu, Jocelyn
dc.contributor.authorRaja, Katherine
dc.contributor.authorKelley, Emily
dc.contributor.authorHerr, Daniel
dc.contributor.authorVannella, Kevin M
dc.contributor.authorRavichandran, Supriya
dc.contributor.authorTang, Juanjie
dc.contributor.authorHarris, Anthony
dc.contributor.authorSajadi, Mohammad
dc.contributor.authorChertow, Daniel S
dc.contributor.authorGrazioli, Alison
dc.contributor.authorKhurana, Surender
dc.date.accessioned2022-03-22T14:18:56Z
dc.date.available2022-03-22T14:18:56Z
dc.date.issued2022-03-14
dc.identifier.urihttp://hdl.handle.net/10713/18315
dc.description.abstractBackground: Limited knowledge exists in post-partum women regarding durability of SARS-CoV-2 vaccine-induced antibody responses and their neutralising ability against SARS-CoV-2 variants of concern (VOC). Methods: We elucidated longitudinal mRNA vaccination-induced antibody profiles of 13 post-partum and 13 non-post-partum women (control). Findings: The antibody neutralisation titres against SARS-CoV-2 WA-1 strain were comparable between post-partum and non-post-partum women and these levels were sustained up to four months post-second vaccination in both groups. However, neutralisation titers declined against several VOCs, including Beta and Delta. Higher antibody binding was observed against SARS-CoV-2 receptor-binding domain (RBD) mutants with key VOC amino acids when tested with post-second vaccination plasma from post-partum women compared with controls. Importantly, post-vaccination plasma antibody affinity against VOCs RBDs was significantly higher in post-partum women compared with controls. Interpretation: This study demonstrates that there is a differential vaccination-induced immune responses in post-partum women compared with non-post-partum women, which could help inform future vaccination strategies for these groups.en_US
dc.description.urihttps://doi.org/10.1016/j.ebiom.2022.103940en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEBioMedicineen_US
dc.rightsPublished by Elsevier B.V.en_US
dc.subjectAffinity maturationen_US
dc.subjectCOVID-19en_US
dc.subjectNeutralisationen_US
dc.subjectSARS-CoV-2en_US
dc.subjectSpikeen_US
dc.subjectVaccineen_US
dc.titleSARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum women.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ebiom.2022.103940
dc.identifier.pmid35301181
dc.source.journaltitleEBioMedicine
dc.source.volume77
dc.source.beginpage103940
dc.source.endpage
dc.source.countryNetherlands


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