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dc.contributor.authorHoffman, Seth A
dc.contributor.authorDesai, Sachin N
dc.contributor.authorSikorski, Michael J
dc.contributor.authorFatupaito, Glenn
dc.contributor.authorTupua, Siaosi
dc.contributor.authorThomsen, Robert E
dc.contributor.authorRambocus, Savitra
dc.contributor.authorNimarota-Brown, Susana
dc.contributor.authorPunimata, Linatupu L
dc.contributor.authorSialeipata, Michelle
dc.contributor.authorTuilagi, Chandler F
dc.contributor.authorHan, Jane
dc.contributor.authorRobins-Browne, Roy M
dc.contributor.authorNaseri, Take K
dc.contributor.authorLevine, Myron M
dc.date.accessioned2022-03-21T13:19:22Z
dc.date.available2022-03-21T13:19:22Z
dc.date.issued2022-01-10
dc.identifier.urihttp://hdl.handle.net/10713/18301
dc.description.abstractApproximately 90% of chronic typhoid carriers with persistent Salmonella enterica serovar Typhi (S. Typhi) gallbladder infection have gallstones. In Samoa, where typhoid fever has been endemic for many decades, risk factors predisposing to the development of gallstones are increasing among adults. The Samoa Typhoid Fever Control Program dispatches a "Typhoid Epidemiologic SWAT Team" to perform a household investigation of every blood culture-confirmed case of acute typhoid fever. Investigations include screening household contacts to detect chronic carriers. Following limited training, two nonexpert ultrasound operators performed point-of-care ultrasound (POCUS) on 120 Samoan adults from August to September 2019 to explore the feasibility of POCUS to detect individuals with gallstones during household investigations and community screenings. POCUS scans from 120 Samoan adults in three cohorts (28 food handlers, two typhoid cases and their 18 household contacts, and 72 attendees at an ambulatory clinic) were reviewed by a board-certified radiologist who deemed 96/120 scans (80%) to be interpretable. Compared with the radiologist (gold standard), the nonexpert operators successfully detected 6/7 Samoans with gallstones (85.7% sensitivity) and correctly identified 85/89 without gallstones (95.5% specificity). The proportion (24/120) of uninterpretable scans from this pilot that used minimally trained clinicians (who are neither radiologists nor ultrasound technicians) indicates the need for additional training of POCUS operators. Nevertheless, this pilot feasibility study engenders optimism that in the Samoan setting nonexperts can be trained to use POCUS to diagnose cholelithiasis, thereby helping (along with stool cultures and Vi serology) to identify possible chronic S. Typhi carriers.en_US
dc.description.urihttps://doi.org/10.4269/ajtmh.21-0973en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_US
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygieneen_US
dc.titlePoint-of-Care Ultrasound by Nonexpert Operators Demonstrates High Sensitivity and Specificity in Detecting Gallstones: Data from the Samoa Typhoid Fever Control Program.en_US
dc.typeArticleen_US
dc.identifier.doi10.4269/ajtmh.21-0973
dc.identifier.pmid35008059
dc.source.journaltitleThe American journal of tropical medicine and hygiene
dc.source.volume106
dc.source.issue3
dc.source.beginpage798
dc.source.endpage804
dc.source.countryUnited States


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