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dc.contributor.authorAraszkiewicz, Antonina M.
dc.contributor.authorOliveira, Eduarda P.
dc.contributor.authorSvendsen, Terje
dc.contributor.authorDrela, Katarzyna
dc.contributor.authorRogujski, Piotr
dc.contributor.authorMalysz-Cymborska, Izabela
dc.contributor.authorFiedorowicz, Michal
dc.contributor.authorReis, Rui L.
dc.contributor.authorOliveira, Joaquim Miguel
dc.contributor.authorWalczak, Piotr
dc.contributor.authorJanowski, Miroslaw
dc.contributor.authorLukomska, Barbara
dc.contributor.authorStanaszek, Luiza
dc.date.accessioned2022-03-02T14:16:58Z
dc.date.available2022-03-02T14:16:58Z
dc.date.issued2022-03-01
dc.identifier.urihttp://hdl.handle.net/10713/18133
dc.description.abstractCell transplantation has been studied extensively as a therapeutic strategy for neurological disorders. However, to date, its effectiveness remains unsatisfactory due to low precision and efficacy of cell delivery; poor survival of transplanted cells; and inadequate monitoring of their fate in vivo. Fortunately, different bio-scaffolds have been proposed as cell carriers to improve the accuracy of cell delivery, survival, differentiation, and controlled release of embedded stem cells. The goal of our study was to establish hydrogel scaffolds suitable for stem cell delivery that also allow non-invasive magnetic resonance imaging (MRI). We focused on alginate-based hydrogels due to their natural origin, biocompatibility, resemblance to the extracellular matrix, and easy manipulation of gelation processes. We optimized the properties of alginate-based hydrogels, turning them into suitable carriers for transplanted cells. Human adipose-derived stem cells embedded in these hydrogels survived for at least 14 days in vitro. Alginate-based hydrogels were also modified successfully to allow their injectability via a needle. Finally, supplementing alginate hydrogels with Mn ions or Mn nanoparticles allowed for their visualization in vivo using manganese-enhanced MRI. We demonstrated that modified alginate-based hydrogels can support therapeutic cells as MRI-detectable matrices. © 2022 by the authors.en_US
dc.description.sponsorshipFundação para a Ciência e a Tecnologiaen_US
dc.description.urihttps://doi.org/10.3390/ijms23052465en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.subjectAlginateen_US
dc.subjectBio-scaffoldsen_US
dc.subjectCentral nervous systemen_US
dc.subjectHydrogelsen_US
dc.subjectManganeseen_US
dc.subjectMRIen_US
dc.subjectStem cellsen_US
dc.titleManganese-Labeled Alginate Hydrogels for Image-Guided Cell Transplantationen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms23052465
dc.source.journaltitleInternational Journal of Molecular Sciences
dc.source.volume23
dc.source.issue5


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