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dc.contributor.authorFranco, Daniela
dc.contributor.authorWulff, Andreas B
dc.contributor.authorLobo, Mary Kay
dc.contributor.authorFox, Megan E
dc.date.accessioned2022-03-01T17:44:59Z
dc.date.available2022-03-01T17:44:59Z
dc.date.issued2022-02-10
dc.identifier.urihttp://hdl.handle.net/10713/18131
dc.description.abstractChronic stress can increase the risk of developing a substance use disorder in vulnerable individuals. Numerous models have been developed to probe the underlying neurobiological mechanisms, however, most prior work has been restricted to male rodents, conducted only in rats, or introduces physical injury that can complicate opioid studies. Here we sought to establish how chronic psychosocial stress influences fentanyl consumption in male and female C57BL/6 mice. We used chronic social defeat stress (CSDS), or the modified vicarious chronic witness defeat stress (CWDS), and used social interaction to stratify mice as stress-susceptible or resilient. We then subjected mice to a 15 days fentanyl drinking paradigm in the home cage that consisted of alternating forced and choice periods with increasing fentanyl concentrations. Male mice susceptible to either CWDS or CSDS consumed more fentanyl relative to unstressed mice. CWDS-susceptible female mice did not differ from unstressed mice during the forced periods, but showed increased preference for fentanyl over time. We also found decreased expression of nucleus accumbens Rho GTPases in male, but not female mice following stress and fentanyl drinking. We also compare fentanyl drinking behavior in mice that had free access to plain water throughout. Our results indicate that stress-sensitized fentanyl consumption is dependent on both sex and behavioral outcomes to stress.en_US
dc.description.urihttps://doi.org/10.3389/fnbeh.2022.821080en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Behavioral Neuroscienceen_US
dc.rightsCopyright © 2022 Franco, Wulff, Lobo and Fox.en_US
dc.subjectchronic stressen_US
dc.subjectfentanylen_US
dc.subjectnucleus accumbensen_US
dc.subjectsex differencesen_US
dc.subjectsynthetic opioidsen_US
dc.titleChronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice.en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fnbeh.2022.821080
dc.identifier.pmid35221946
dc.source.journaltitleFrontiers in behavioral neuroscience
dc.source.volume16
dc.source.beginpage821080
dc.source.endpage
dc.source.countrySwitzerland


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