Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice.
JournalFrontiers in Behavioral Neuroscience
PublisherFrontiers Media S.A.
MetadataShow full item record
AbstractChronic stress can increase the risk of developing a substance use disorder in vulnerable individuals. Numerous models have been developed to probe the underlying neurobiological mechanisms, however, most prior work has been restricted to male rodents, conducted only in rats, or introduces physical injury that can complicate opioid studies. Here we sought to establish how chronic psychosocial stress influences fentanyl consumption in male and female C57BL/6 mice. We used chronic social defeat stress (CSDS), or the modified vicarious chronic witness defeat stress (CWDS), and used social interaction to stratify mice as stress-susceptible or resilient. We then subjected mice to a 15 days fentanyl drinking paradigm in the home cage that consisted of alternating forced and choice periods with increasing fentanyl concentrations. Male mice susceptible to either CWDS or CSDS consumed more fentanyl relative to unstressed mice. CWDS-susceptible female mice did not differ from unstressed mice during the forced periods, but showed increased preference for fentanyl over time. We also found decreased expression of nucleus accumbens Rho GTPases in male, but not female mice following stress and fentanyl drinking. We also compare fentanyl drinking behavior in mice that had free access to plain water throughout. Our results indicate that stress-sensitized fentanyl consumption is dependent on both sex and behavioral outcomes to stress.
Rights/TermsCopyright © 2022 Franco, Wulff, Lobo and Fox.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18131
- Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress.
- Authors: Francis TC, Chandra R, Friend DM, Finkel E, Dayrit G, Miranda J, Brooks JM, Iñiguez SD, O'Donnell P, Kravitz A, Lobo MK
- Issue date: 2015 Feb 1
- Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress.
- Authors: Engeln M, Fox ME, Lobo MK
- Issue date: 2021 Jan
- Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.
- Authors: Guo Q, Wang L, Yuan W, Li L, Zhang J, Hou W, Yang Y, Zhang X, Cai W, Ma H, Xun Y, Jia R, He Z, Tai F
- Issue date: 2020 Apr 20
- Reproducible induction of depressive-like behavior in C57BL/6J mice exposed to chronic social defeat stress with a modified sensory contact protocol.
- Authors: Kamimura Y, Kuwagaki E, Hamano S, Kobayashi M, Yamada Y, Takahata Y, Yoshimoto W, Morimoto H, Yasukawa T, Uozumi Y, Nagasawa K
- Issue date: 2021 Oct 1
- mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress.
- Authors: Xu X, Wu K, Ma X, Wang W, Wang H, Huang M, Luo L, Su C, Yuan T, Shi H, Han J, Wang A, Xu T
- Issue date: 2021 Oct