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    Isolated Gastritis Secondary to Immune Checkpoint Inhibitors Complicated by Superimposed Cytomegalovirus Infection.

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    Author
    Nguyen, Anita H
    Sagvand, Babak Torabi
    Hwang, Daniel G
    Legesse, Teklu
    Cross, Raymond K
    Date
    2022-02-23
    Journal
    ACG Case Reports Journal
    Publisher
    Wolters Kluwer Health
    Type
    Article
    
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    See at
    https://doi.org/10.14309/crj.0000000000000747
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8869562/
    Abstract
    Immune checkpoint inhibitors such as nivolumab increase the T-cell destruction of malignancies but can also trigger a broad variety of immune-related adverse events (irAEs). Colitis as an irAE is well-documented, but upper gastrointestinal tract involvement is primarily unrecognized. We present a patient who developed gastritis as an irAE after multiple cycles of nivolumab and initially responded well to steroid therapy but then developed superimposed cytomegalovirus infection. The similarity between both presentations highlights the importance of having a broad differential diagnosis in patients with gastrointestinal complaints treated with immune checkpoint inhibitors and the need for further studies to better characterize gastritis as an irAE.
    Rights/Terms
    © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18129
    ae974a485f413a2113503eed53cd6c53
    10.14309/crj.0000000000000747
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