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    Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: Sex differences in rats.

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    Author
    D'Ottavio, Ginevra
    Reverte, Ingrid
    Ragozzino, Davide
    Meringolo, Maria
    Milella, Michele Stanislaw
    Boix, Fernando
    Venniro, Marco
    Badiani, Aldo
    Caprioli, Daniele
    Date
    2022-01-05
    Journal
    British Journal of Pharmacology
    Publisher
    Wiley-Blackwell
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1111/bph.15791
    Abstract
    Rats were trained to self-administer a palatable solution and then heroin (0.075 mg·kg-1 per inf) either continuously (6 h·day-1 ; 10 days) or intermittently (6 h·day-1 ; 5-min access every 30-min; 10 days). Brain levels of heroin and its metabolites were modelled using a pharmacokinetic software. Next, heroin-seeking was assessed after 1 or 21 abstinence days. Between tests, rats underwent either forced or voluntary abstinence. The oestrous cycle was measured using a vaginal smear test.
    Rights/Terms
    © 2022 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
    Keyword
    6-monoacetylmorphine
    heroin
    incubation of craving
    intermittent access
    pharmacokinetics
    relapse
    sex differences
    voluntary abstinence
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/18103
    ae974a485f413a2113503eed53cd6c53
    10.1111/bph.15791
    Scopus Count
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