Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: Sex differences in rats.
Author
D'Ottavio, GinevraReverte, Ingrid
Ragozzino, Davide
Meringolo, Maria
Milella, Michele Stanislaw
Boix, Fernando
Venniro, Marco
Badiani, Aldo
Caprioli, Daniele
Date
2022-01-05Journal
British Journal of PharmacologyPublisher
Wiley-BlackwellType
Article
Metadata
Show full item recordAbstract
Rats were trained to self-administer a palatable solution and then heroin (0.075 mg·kg-1 per inf) either continuously (6 h·day-1 ; 10 days) or intermittently (6 h·day-1 ; 5-min access every 30-min; 10 days). Brain levels of heroin and its metabolites were modelled using a pharmacokinetic software. Next, heroin-seeking was assessed after 1 or 21 abstinence days. Between tests, rats underwent either forced or voluntary abstinence. The oestrous cycle was measured using a vaginal smear test.Rights/Terms
© 2022 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.Keyword
6-monoacetylmorphineheroin
incubation of craving
intermittent access
pharmacokinetics
relapse
sex differences
voluntary abstinence
Identifier to cite or link to this item
http://hdl.handle.net/10713/18103ae974a485f413a2113503eed53cd6c53
10.1111/bph.15791
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