Microtubule disruption reduces metastasis more effectively than primary tumor growth.
AuthorThompson, Keyata N
Ju, Julia A
Ory, Eleanor C
Pratt, Stephen J P
Lee, Rachel M
Mathias, Trevor J
Chang, Katarina T
Lee, Cornell J
Goloubeva, Olga G
Bailey, Patrick C
Chakrabarti, Kristi R
Jewell, Christopher M
Vitolo, Michele I
Martin, Stuart S
JournalBreast Cancer Research : BCR
MetadataShow full item record
AbstractClinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor cell viability. Treating mice with Vinorelbine for only 24 h had no significant effect on primary tumor survival, but median metastatic tumor survival was extended from 8 to 30 weeks. Microtentacle inhibition by Vinorelbine was also detectable within 1 h, using tumor cells isolated from blood samples. As few as 11 tumor cells were sufficient to yield 90% power to detect this 1 h Vinorelbine drug response, demonstrating feasibility with the small number of tumor cells available from patient biopsies. This study establishes a proof-of-concept that targeted microtubule disruption can selectively inhibit metastasis and reveals that existing FDA-approved therapies could have anti-metastatic actions that are currently overlooked when focusing exclusively on tumor growth.
Rights/Terms© 2022. The Author(s).
Circulating tumor cells
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/18010
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