Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia: A Prospective Multicenter Cohort Study (VENOUS I).

Contreras, German A; Munita, Jose M; Simar, Shelby; Luterbach, Courtney; Dinh, An Q; Rydell, Kirsten; Sahasrabhojane, Pranoti V; Rios, Rafael; Diaz, Lorena; Reyes, Katherine; Zervos, Marcus; Misikir, Helina M; Sanchez-Petitto, Gabriela; Liu, Catherine; Doi, Yohei; Abbo, Lilian M; Shimose, Luis; Seifert, Harald; Gudiol, Carlota; Barberis, Fernanda; Pedroza, Claudia; Aitken, Samuel L; Shelburne, Samuel A; van Duin, David; Tran, Truc T; Hanson, Blake M; Arias, Cesar A

Date

2021-12-23

Journal

Open Forum Infectious Diseases

Publisher

Oxford University Press

Type

Article

Metadata

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See at

https://doi.org/10.1093/ofid/ofab616

Abstract

The Vancomycin-Resistant Enterococcal BSI Outcomes Study (VENOUS I) is a prospective observational cohort of adult patients with enterococcal BSI in 11 US hospitals. We included patients with Enterococcus faecalis or Enterococcus faecium BSI with ≥1 follow-up blood culture(s) within 7 days and availability of isolate(s) for further characterization. The primary study outcome was in-hospital mortality. Secondary outcomes were mortality at days 4, 7, 10, 12, and 15 after index blood culture. A desirability of outcome ranking was constructed to assess the association of vancomycin resistance with outcomes. All index isolates were subjected to whole genome sequencing.

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