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dc.contributor.authorJentzer, Jacob C
dc.contributor.authorBhat, Anusha G
dc.contributor.authorPatlolla, Sri Harsha
dc.contributor.authorSinha, Shashank S
dc.contributor.authorMiller, P Elliott
dc.contributor.authorLawler, Patrick R
dc.contributor.authorvan Diepen, Sean
dc.contributor.authorKhanna, Ashish K
dc.contributor.authorZhao, David X
dc.contributor.authorVallabhajosyula, Saraschandra
dc.date.accessioned2022-02-14T15:35:47Z
dc.date.available2022-02-14T15:35:47Z
dc.date.issued2022-02-04
dc.identifier.urihttp://hdl.handle.net/10713/17976
dc.description.abstractOutcomes of interest included inhospital mortality, development of noncardiac organ failure, complications, utilization of guideline-directed procedures, length of stay, and hospitalization costs. Over 15 years, 444,253 AMI-CS admissions were identified, of which 27,057 (6%) included sepsis. The sepsis cohort had more comorbidities and had higher rates of noncardiac multiple organ failure (92% vs 69%) (all p < 0.001). In 2014, compared with 2000, the prevalence of sepsis increased from 0.5% versus 11.5% with an adjusted odds ratio (aOR) 11.71 (95% CI, 9.7-14.0) in ST-segment elevation myocardial infarction and 24.6 (CI, 16.4-36.7) (all p < 0.001) in non-ST segment elevation myocardial infarction. The sepsis cohort received fewer cardiac interventions (coronary angiography [65% vs 68%], percutaneous coronary intervention [43% vs 48%]) and had greater use of mechanical circulatory support (48% vs 45%) and noncardiac support (invasive mechanical ventilation [65% vs 41%] and acute hemodialysis [12% vs 3%]) (p < 0.001). The sepsis cohort had higher inhospital mortality (44.3% vs 38.1%; aOR, 1.21; 95% CI, 1.18-1.25; p < 0.001), longer length of stay (14.0 d [7-24 d] vs 7.0 d [3-12 d]), greater hospitalization costs (×1,000 U.S. dollars) ($176.0 [$85-$331] vs $77.0 [$36-$147]), fewer discharges to home (22% vs 44%) and more discharges to skilled nursing facilities (51% vs 28%) (all p < 0.001).en_US
dc.description.urihttps://doi.org/10.1097/CCE.0000000000000637en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8820909/en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.ispartofCritical Care Explorationsen_US
dc.rightsCopyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.en_US
dc.subjectacute myocardial infarctionen_US
dc.subjectcardiogenic shocken_US
dc.subjectcirculatory shocken_US
dc.subjectcritical care cardiologyen_US
dc.subjectsepsisen_US
dc.titleConcomitant Sepsis Diagnoses in Acute Myocardial Infarction-Cardiogenic Shock: 15-Year National Temporal Trends, Management, and Outcomes.en_US
dc.typeArticleen_US
dc.identifier.doi10.1097/CCE.0000000000000637
dc.identifier.pmid35141527
dc.source.journaltitleCritical care explorations
dc.source.volume4
dc.source.issue2
dc.source.beginpagee0637
dc.source.endpage
dc.source.countryUnited States


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