Show simple item record

dc.contributor.authorDu, Heng
dc.contributor.authorYang, Wenjie
dc.contributor.authorChen, Xiangyan
dc.date.accessioned2022-02-14T14:47:50Z
dc.date.available2022-02-14T14:47:50Z
dc.date.issued2022-01-24
dc.identifier.urihttp://hdl.handle.net/10713/17974
dc.description.abstractIntracranial artery calcification (IAC) was regarded as a proxy for intracranial atherosclerosis (ICAS). IAC could be easily detected on routine computer tomography (CT), which was neglected by clinicians in the previous years. The evolution of advanced imaging technologies, especially vessel wall scanning using high resolution-magnetic resonance imaging (HR-MRI), has aroused the interest of researchers to further explore the characteristics and clinical impacts of IAC. Recent histological evidence acquired from the human cerebral artery specimens demonstrated that IAC could mainly involve two layers: the intima and the media. Accumulating evidence from histological and clinical imaging studies verified that intimal calcification is more associated with ICAS, while medial calcification, especially the internal elastic lamina, contributes to arterial stiffness rather than ICAS. Considering the highly improved abilities of novel imaging technologies in differentiating intimal and medial calcification within the large intracranial arteries, this review aimed to describe the histological and imaging features of two types of IAC, as well as the risk factors, the hemodynamic influences, and other clinical impacts of IAC occurring in intimal or media layers.en_US
dc.description.urihttps://doi.org/10.3389/fneur.2021.789035en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Neurologyen_US
dc.rightsCopyright © 2022 Du, Yang and Chen.en_US
dc.subjectcerebrovascular diseaseen_US
dc.subjectclinical relevanceen_US
dc.subjecthistologyen_US
dc.subjectimagingen_US
dc.subjectintracranial artery calcificationen_US
dc.titleHistology-Verified Intracranial Artery Calcification and Its Clinical Relevance With Cerebrovascular Disease.en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fneur.2021.789035
dc.identifier.pmid35140673
dc.source.journaltitleFrontiers in neurology
dc.source.volume12
dc.source.beginpage789035
dc.source.endpage
dc.source.countrySwitzerland


This item appears in the following Collection(s)

Show simple item record