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    Reply to Rose et al.

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    Author
    Anderson, Evan J
    Kamidani, Satoshi
    Orenstein, Walt
    Campbell, James D
    Date
    2022-01
    Journal
    Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/cid/ciab400
    Abstract
    TO THE EDITOR—We agree that optimal drug doses in those ≥12 years of age have been similar to those identified for adults [1, 2]. Neither of our articles addressed the complexity of pediatric drug development [3, 4]. Importantly, the bar for vaccine licensure in healthy children is different from that for administration of a potentially lifesaving therapeutic. In addition, classic pharmacokinetic data (eg, clearance, volume of distribution) do not exist for locally administered vaccines. As such, we need to determine the vaccine dose and schedule from clinical trial data. While we can use “our present understanding of the developing human body” [2] as a starting point for rational clinical trials, we owe our children data on which to base vaccine licensure...
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17882
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciab400
    Scopus Count
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    UMB Coronavirus Publications
    UMB Open Access Articles

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