Immunological Diversity Is a Cornerstone of Organismal Defense and Allorecognition across Metazoa.
JournalJournal of Immunology (Baltimore, Md. : 1950)
PublisherAmerican Association of Immunologists
MetadataShow full item record
AbstractThe ongoing arms race between hosts and microbes has fueled the evolution of novel strategies for diversifying the molecules involved in immune responses. Characterization of immune systems from an ever-broadening phylogenetic range of organisms reveals that there are many mechanisms by which this diversity can be generated and maintained. Diversification strategies operate at the level of populations, genomes, genes, and even individual transcripts. Lineage-specific innovations have been cataloged within the immune systems of both invertebrates and vertebrates. Furthermore, somatic diversification of immune receptor genes has now been described in jawless vertebrates and some invertebrate species. In addition to pathogen detection, immunological diversity plays important roles in several distinct allorecognition systems. In this Brief Review, we highlight some of the evolutionary innovations employed by a variety of metazoan species to generate the molecular diversity required to detect a vast array of molecules in the context of both immune response and self/nonself-recognition.
Rights/TermsCopyright © 2022 by The American Association of Immunologists, Inc.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/17880
- Reconstructing immune phylogeny: new perspectives.
- Authors: Litman GW, Cannon JP, Dishaw LJ
- Issue date: 2005 Nov
- New insights into alternative mechanisms of immune receptor diversification.
- Authors: Litman GW, Cannon JP, Rast JP
- Issue date: 2005
- Evolution of adaptive immune recognition in jawless vertebrates.
- Authors: Saha NR, Smith J, Amemiya CT
- Issue date: 2010 Feb
- The evolution of adaptive immunity in vertebrates.
- Authors: Hirano M, Das S, Guo P, Cooper MD
- Issue date: 2011
- Origin and evolution of adaptive immunity.
- Authors: Boehm T, Swann JB
- Issue date: 2014 Feb