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    Cochrane systematic reviews on traditional Chinese medicine: What matters-the quantity or quality of evidence?

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    Author
    Dai, Zeqi
    Liao, Xing
    Wieland, L Susan
    Hu, Jing
    Wang, Yongyan
    Kim, Tae-Hun
    Liu, Jian-Ping
    Zhan, Siyan
    Robinson, Nicola
    Date
    2022-01-10
    Journal
    Phytomedicine
    Publisher
    Elsevier
    Type
    Article
    
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    https://doi.org/10.1016/j.phymed.2021.153921
    Abstract
    Background: Systematic reviews on traditional Chinese medicine (TCM) are constantly increasing. However, if these reviews are to be of practical value, the evidence needs to be relevant, valid, and adequately reported. Cochrane Systematic Reviews (CSRs) are considered as high-quality systematic reviews that can inform health care decision making. Our aim was to provide an overview of the scope, findings, quality and impact of CSRs on the benefits and harms associated with TCM interventions for the treatment and prevention of disease to provide new information for clinical practice and future research. Methods: The Cochrane Database of Systematic Reviews was searched up to May 2021, and descriptive characteristics were extracted. The correspondence between the questions asked in the CSRs and the available evidence, conclusions and certainty of findings (according to GRADE assessment), methodological quality (AMSTAR 2), and impact (Altmetric Attention Score [AAS], total citations by guideline, and total citations in Web of Science [WoS]) of CSRs were extracted. Tabular and graphical summaries of these descriptive characteristics were constructed. Results: Of 104 CSRs on TCM identified, 70 diseases belonged to 16 disease systems and contained 1642 primary studies with 157,943 participants. Interventions included Chinese herbal medicine (n = 70), acupuncture (n = 28), TCM exercises (n = 4), and moxibustion (n = 2). Among 1642 primary studies, 662 studies included an intervention group treated with at least one TCM therapy and 980 studies included a combination of therapies. Promising outcomes from the 104 CSRs were divided into endpoint outcomes (34 diseases), doctor- or patient-reported outcomes (27 diseases), and surrogate outcomes (37 diseases). Despite the presence of promising outcomes, only 5/104 CSRs drew overall positive conclusions, 42 CSRs concluded the evidence was insufficient, and 54 failed to draw firm conclusions. GRADE assessments were reported in 41.3% of the CSRs, and the ratings were mostly low or very low. Comparing the questions asked and results obtained, there was frequently a lack of information about specific outcomes. Only 16 CSRs obtained results for all outcomes listed in the methods section. According to AMSTAR 2, 51 CSRs (49.0%) were of low quality. The total number of citations in the WoS was 2135 (mean ± SD: 20.8 ± 21.2), and 38.5% of the CSRs had been cited in guidelines 95 times. Conclusion: Although TCM is commonly used, evidence of its effectiveness remains largely inconclusive. Rigorous high-quality trials are needed to support the performance of high-quality reviews and to increase the evidence base. It is critical to emphasize quality over quantity in future TCM research. © 2022 The Author(s)
    Rights/Terms
    Copyright © 2022 The Author(s). Published by Elsevier GmbH.. All rights reserved.
    Keyword
    Cochrane systematic review
    Evidence
    Overview
    Quality assessment
    Traditional Chinese medicine
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17879
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.phymed.2021.153921
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