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dc.contributor.authorBarandouzi, Zahra A
dc.contributor.authorLee, Joochul
dc.contributor.authorDel Carmen Rosas, Maria
dc.contributor.authorChen, Jie
dc.contributor.authorHenderson, Wendy A
dc.contributor.authorStarkweather, Angela R
dc.contributor.authorCong, Xiaomei S
dc.date.accessioned2022-02-04T14:19:03Z
dc.date.available2022-02-04T14:19:03Z
dc.date.issued2022-01-31
dc.identifier.urihttp://hdl.handle.net/10713/17876
dc.description.abstractEvidence highlights the comorbidity between emotional distress and irritable bowel syndrome (IBS) through the gut-brain axis. However, the underlying mechanism is largely unknown. Thus, the present study aimed to evaluate the associations among neurotransmitter levels and the gut microbiome profiles in persons with IBS and emotional distress. In this nested case-controlled study, emotional symptoms, including anxiety and depressive symptoms, were evaluated in 40 persons with IBS and 20 healthy controls (HC). Plasma neurotransmitters levels (serotonin and norepinephrine) and the gut microbiome profile of the collected fecal samples were examined. Emotional distress and microbiome profile were significantly different between IBS and HC groups. Lower but not significant neurotransmitters' levels (serotonin and norepinephrine) were observed in the IBS group compared to the HC. A negative correlation was found between norepinephrine levels and alpha diversity (Shannon and Simpson indices) in the IBS group. Moreover, serotonin levels were positively associated with the abundance of Proteobacteria, and norepinephrine were positively correlated with Bacteroidetes, but negatively associated with Firmicutes phylum. The present study demonstrated alteration in the gut microbiome between persons with IBS and emotional distress compared to HC. The correlations between plasma neurotransmitters and the gut microbiome suggest that the gut microbiome may impact the regulation of neurotransmitters.en_US
dc.description.urihttps://doi.org/10.1038/s41598-022-05756-0en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8803858/en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofScientific Reportsen_US
dc.rights© 2022. The Author(s).en_US
dc.titleAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome.en_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-022-05756-0
dc.identifier.pmid35102266
dc.source.journaltitleScientific reports
dc.source.volume12
dc.source.issue1
dc.source.beginpage1648
dc.source.endpage
dc.source.countryEngland


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