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    Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome.

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    Author
    Barandouzi, Zahra A
    Lee, Joochul
    Del Carmen Rosas, Maria
    Chen, Jie
    Henderson, Wendy A
    Starkweather, Angela R
    Cong, Xiaomei S
    Date
    2022-01-31
    Journal
    Scientific Reports
    Publisher
    Springer Nature
    Type
    Article
    
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    See at
    https://doi.org/10.1038/s41598-022-05756-0
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8803858/
    Abstract
    Evidence highlights the comorbidity between emotional distress and irritable bowel syndrome (IBS) through the gut-brain axis. However, the underlying mechanism is largely unknown. Thus, the present study aimed to evaluate the associations among neurotransmitter levels and the gut microbiome profiles in persons with IBS and emotional distress. In this nested case-controlled study, emotional symptoms, including anxiety and depressive symptoms, were evaluated in 40 persons with IBS and 20 healthy controls (HC). Plasma neurotransmitters levels (serotonin and norepinephrine) and the gut microbiome profile of the collected fecal samples were examined. Emotional distress and microbiome profile were significantly different between IBS and HC groups. Lower but not significant neurotransmitters' levels (serotonin and norepinephrine) were observed in the IBS group compared to the HC. A negative correlation was found between norepinephrine levels and alpha diversity (Shannon and Simpson indices) in the IBS group. Moreover, serotonin levels were positively associated with the abundance of Proteobacteria, and norepinephrine were positively correlated with Bacteroidetes, but negatively associated with Firmicutes phylum. The present study demonstrated alteration in the gut microbiome between persons with IBS and emotional distress compared to HC. The correlations between plasma neurotransmitters and the gut microbiome suggest that the gut microbiome may impact the regulation of neurotransmitters.
    Rights/Terms
    © 2022. The Author(s).
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17876
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-022-05756-0
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